Endemic maintenance of human-related hepatitis E virus strains in synurbic wild boars, Barcelona Metropolitan Area, Spain
Ruiz-Ponsell, Laia (Banc de Sang i Teixits de Catalunya)
Monastiri, Abir (Universitat de Barcelona)
López-Roig, Marc (Universitat de Barcelona)
Sauleda, Sílvia (Banc de Sang i Teixits de Catalunya)
Bes, Marta (Banc de Sang i Teixits de Catalunya)
Mentaberre García, Gregorio (Universitat de Lleida. Departament de Ciència Animal)
Escobar-González, María (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Costafreda Salvany, Maria Isabel (Universitat de Barcelona)
López Olvera, Jorge R (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Serra-Cobo, Jordi (Universitat de Barcelona. Institut de Recerca de la Biodiversitat (IRBio))

Data:	2024
Resum:	Hepatitis E virus (HEV), shared by humans, domestic animals, and wildlife, is an emerging global public health threat. Because wild boars are a major reservoir of HEV, the new zoonotic interfaces resulting from wild boar population increase and synurbization significantly contribute to increasing the risk of zoonotic transmission of HEV. This study characterizes HEV strains of synurbic wild boars and assesses their relationship with sympatric human and domestic swine HEV strains. We analyzed the faeces of 312 synurbic wild boars collected from 2016 to 2021 in the Barcelona Metropolitan Area (BMA), where there is a high density of wild boars, and found 7 HEV-positive samples among those collected between 2019 and 2020. The molecular analysis of these isolates, along with 6 additional wild boar HEV isolates from a previous study, allowed us to establish a close phylogenetic relationship between these HEV strains and human HEV isolates from sympatric blood donors and domestic pigs from Catalonia. HEV-positive wild boar samples belonged to piglet, juvenile and yearling individuals, but not adults, indicating the endemic maintenance of HEV in the wild boar population of the BMA by naïve young individuals. All wild boar HEV isolates in this study classified within HEV genotype 3. The results show, for the first time, a close molecular similarity between the HEV strains endemically maintained by the synurbic wild boars in the BMA and citizens from the same area and period. The data could also indicate that HEV infection presents a seasonal and interannual variability in wild boars of BMA. Further investigation is required to unveil the HEV transmission routes between synurbic wild boars and sympatric citizens. These findings can serve in other synurbic wildlife-human interfaces throughout the world.
Ajuts:	Agencia Estatal de Investigación CEX2021-001234-M
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Animals ; Hepatitis E virus/isolation & purification ; Spain ; Sus scrofa ; Hepatitis E/epidemiology ; Swine ; Humans ; Swine Diseases/virology ; Phylogeny ; Zoonoses/virology ; Feces/virology ; Genotype ; SDG 3 - Good Health and Well-being
Publicat a:	Science of the total environment, Vol. 955 (2024) , p. 176871, ISSN 1879-1026

DOI: 10.1016/j.scitotenv.2024.176871
PMID: 39395489

7 p, 1.8 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Grup de recerca Wildlife Ecology & Health
Articles > Articles de recerca
Articles > Articles publicats