The effectiveness of mapping-targeted biopsies on the index lesion in transperineal prostate biopsies
Paesano, Nahuel (Hospital de la Creu Blanca (Barcelona))
Català, Violeta (Hospital de la Creu Blanca (Barcelona))
Tcholakian, Larisa (Hospital de la Creu Blanca (Barcelona))
Alomar Serrallach, Xavier (Hospital de la Creu Blanca (Barcelona))
Barranco, Miguel (Hospital de la Creu Blanca (Barcelona))
Trilla Herrera, Enrique (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Morote Robles, Juan (Universitat Autònoma de Barcelona. Departament de Cirurgia)

Data:	2024
Resum:	To evaluate the effectiveness of mapping-targeted biopsies (MTB) on the index lesion for the detection of clinically significant prostate cancer (csPCa) in transperineal fusion-image prostate biopsies. A retrospective analysis was conducted on 309 men with suspected PCa who underwent prostate biopsies at the Creu Blanca reference center in Barcelona, Spain. The Prostate Imaging-Reporting and Data System (PI-RADS v. 2. 1) of the magnetic resonance images (MRI) were reclassified by an expert radiologist reading of pre-biopsy biparametric MRI used for segmentation of suspected lesions. Transperineal MTB of suspicious lesions and 12-core systematic biopsies were performed using the Artemis™ platform. CsPCa was defined as International Society of Urological Pathology grade group ≥ 2. CsPCa was detected in 192 men (62. 1%), with detection rates of 6. 3% for PI-RADS 2, 26. 8% for PI-RADS 3, 87. 3% for PI-RADS 4, and 93. 1% for PI-RADS 5. MTB of the index lesion identified 185 csPCa (96. 3%). CsPCa was detected solely in systematic biopsies in three cases (1. 6%), while an additional four cases (2. 1%) were identified only in the second suspected lesion. A predictive model for csPCa detection in MTB of the index lesion was developed, with an AUC of 0. 918 (95% CI 0. 887-0. 950). This model had the potential to avoid 23. 3% of prostate biopsies without missing additional csPCa cases. MTB of the index lesion was highly effective for identifying csPCa in fusion transperineal prostate biopsies. A developed predictive model successfully reduced the need for almost one quarter of biopsies without missing csPCa cases.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Prostatic Neoplasms ; Prostate ; Retrospective Studies
Publicat a:	International Braz J Urol, Vol. 50 (march 2024) , p. 296-308, ISSN 1677-6119

DOI: 10.1590/S1677-5538.IBJU.2023.0558
PMID: 38446907

13 p, 4.6 MB

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