Trait anxiety is associated with attentional brain networks
De la Peña-Arteaga, Víctor (Institut de Recerca Sant Pau)
Chavarría-Elizondo, Pamela (Hospital Universitari de Bellvitge)
Juaneda-Seguí, Asier (Hospital Universitari de Bellvitge)
Martínez-Zalacaín, Ignacio (Hospital Universitari de Bellvitge)
Morgado, Pedro (2CA-Clinical Academic Center)
Manuel Menchón, José (Hospital Universitari de Bellvitge)
Picó-Pérez, Maria (Universitat Jaume I)
Fullana, Miguel (Hospital Clínic i Provincial de Barcelona)
Soriano-Mas, Carles (Hospital Universitari de Bellvitge)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Trait anxiety is a well-established risk factor for anxiety and depressive disorders, yet its neural correlates are not clearly understood. In this study, we investigated the neural correlates of trait anxiety in a large sample (n = 179) of individuals who completed the trait and state versions of the State-Trait Anxiety Inventory and underwent resting-state functional magnetic resonance imaging. We used independent component analysis to characterize individual resting-state networks (RSNs), and multiple regression analyses to assess the relationship between trait anxiety and intrinsic connectivity. Trait anxiety was significantly associated with intrinsic connectivity in different regions of three RSNs (dorsal attention network, default mode network, and auditory network) when controlling for state anxiety. These RSNs primarily support attentional processes. Notably, when state anxiety was not controlled for, a different pattern of results emerged, highlighting the importance of considering this factor in assessing the neural correlates of trait anxiety. Our findings suggest that trait anxiety is uniquely associated with resting-state brain connectivity in networks mainly supporting attentional processes. Moreover, controlling for state anxiety is crucial when assessing the neural correlates of trait anxiety. These insights may help refine current neurobiological models of anxiety and identify potential targets for neurobiologically-based interventions.
Grants:	Ministerio de Economía y Competitividad PI16/00889 Ministerio de Economía y Competitividad PI16/00144 Instituto de Salud Carlos III PI19/01171 Instituto de Salud Carlos III PI19/00272
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Attention ; Neuroimaging ; Personality traits ; State trait anxiety inventory ; Fmri
Published in:	European neuropsychopharmacology, Vol. 83 (june 2024) , p. 19-26, ISSN 1873-7862

DOI: 10.1016/j.euroneuro.2024.02.013
PMID: 38492550

8 p, 4.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles