Ethylene Oxide Hemoglobin Adducts in Cord Blood and Offspring's Size at Birth : The NewGeneris European Cohort Study
Harding, Barbara N. (Universitat Pompeu Fabra)
Agramunt Garcia, Sílvia (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Pedersen, Marie (DUniversity of Copenhagen)
Knudsen, Lisbeth E. (University of Copenhagen)
Nielsen, Jeanette K. S. (University of Copenhagen)
Wright, John (Bradford Institute for Heath Research)
Vafeiadi, Marina (University of Crete)
Merlo, Domenico F. (Azienda Unità Sanitaria Locale di Reggio Emilia. Instituto in tecnologie avanzate e modelli assistenziali in oncologia)
Stayner, Leslie (UIC School of Public Health (Chicago, Estats Units d'Amèrica))
Kelly-Reif, Kaitlin (National Institute for Occupational Health and Safety (Cincinnati, Estats Units d'Amèrica))
Espinosa, Ana (Institut Hospital del Mar d'Investigacions Mèdiques)
Bustamante, Mariona (Universitat Pompeu Fabra)
Gützkow, Kristine Bjerve (Norwegian Institute of Public Health)
Granum, Berit (Norwegian Institute of Public Health)
von Stedingk, Hans (Stockholm University)
Rydberg, Per (Karolinska Institutet (Estocolm, Suècia))
Alexander, Jan (Norwegian Institute of Public Health)
Törnqvist, Margareta (Stockholm University)
Kogevinas, Manolis (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2024
Resum:	Prenatal ethylene oxide exposure may have adverse effects on fetal development. We examined the relationships between ethylene oxide hemoglobin (Hb) adduct levels and offspring's size at birth in a prospective European mother-child study. This study included 1106 singletons from the NewGeneris project (2006-2010) with ethylene oxide Hb adducts measured in cord blood. We examined the relationships between adduct levels and offspring's size at birth among all infants and separately among infants of nonsmokers, using linear regression models for birth weight and birth head circumference and logarithmic binomial regression models for small for gestational age. We examined potential interactions between CYP2E1 single nucleotide polymorphisms in cord blood and the effects of ethylene oxide Hb adduct levels on offspring birth size. Higher quartiles of adduct levels as a measure of exposure were associated with decreasing birth weight and head circumference in the overall population. Compared to infants in the lowest quartile, those in the highest quartile exhibited lower birth weight (-70. 73 g, 95% confidence interval = -141. 16, -0. 30) and reduced head circumference (-0. 30 cm, 95% confidence interval = -0. 58, -0. 02). We observed similar, albeit less pronounced, patterns among infants of nonsmokers. There was no evidence of an association between ethylene oxide Hb adducts and risk of small for gestational age, nor consistent evidence of an interaction with CYP2E1 polymorphisms on the association between EO Hb adduct levels and offspring's size at birth. Results suggest that higher ethylene oxide Hb adduct levels in cord blood are associated with a reduction in offspring birth size.
Ajuts:	European Commission 758151 European Commission 036224
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Biomarker ; Birth outcomes ; Birth weight ; Ethylene oxide ; Head circumference ; Hemoglobin adducts

DOI: 10.1097/EDE.0000000000001767
PMID: 38935439

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