Spontaneous and perturbation-based EEG cortical excitability markers are associated with plasma p-tau181 concentration in healthy middle-aged adults
Perellón-Alfonso, Ruben (Institut Germans Trias i Pujol. Institut Guttmann)
Abellaneda Pérez, Kilian (Universitat Autònoma de Barcelona)
Pileckyte, Indre (Universitat Pompeu Fabra)
Cabello-Toscano, María (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Mulet-Pons, Lídia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Vaqué-Alcázar, Lídia (Institut d'Investigació Biomèdica Sant Pau)
Cattaneo, Gabriele (Universitat Autònoma de Barcelona)
Redondo-Camós, María (Universitat Autònoma de Barcelona)
España-Irla, Goretti (Northeastern University (Boston, Estats Units d'Amèrica))
Delgado-Gallen, Selma (Universitat Autònoma de Barcelona)
Solana-Sánchez, Javier (Universitat Autònoma de Barcelona)
Zetterberg, Henrik (University of Wisconsin-Madison (Estats Units d'Amèrica))
Tormos, Jose M. (Universidad Católica de Valencia)
Franzmeier, Nicolai (University of Gothenburg (Suècia))
Pascual Leone, Álvaro (Linus Health (Boston, Estats Units d'Amèrica))
Bartrés-Faz, David (Institut Germans Trias i Pujol. Institut Guttmann)

Fecha:	2024
Resumen:	In early-stage Alzheimer's disease (AD) amyloid-β (Aβ) deposition can induce neuronal hyperactivity, thereby potentially triggering activity-dependent neuronal secretion of phosphorylated tau (p-tau), ensuing tau aggregation and spread. Therefore, cortical excitability is a candidate biomarker for early AD detection. Moreover, lowering neuronal excitability could potentially complement strategies to reduce Aβ and tau buildup. There is, however, a lack of understanding of the relationship between cortical excitability and p-tau increase in vivo. Therefore, in a sample of 658 healthy middle-aged (between the ages of 40 and 65) participants of the Barcelona Brain Health Initiative cohort study, we examined the relation of blood-based tau, phosphorylated at amino acid 181 (p-tau181), reflecting neuronal p-tau secretion; neurofilament light chain (NfL), as a passively released control for p-tau181; and electroencephalography (EEG) markers of cortical excitability. A subsample of 47 participants also completed a controlled brain perturbation approach via transcranial magnetic stimulation (TMS) with concurrent EEG. Results show that both spontaneous (i. e. , resting-state) and perturbation-based TMS-EEG markers, are associated with blood p-tau181, particularly in older individuals. The perturbation-based marker was a significantly more sensitive predictor of p-tau181 concentration than the spontaneous resting state EEG-based marker. The relationships observed are not present for the NfL control. These results show that relationships between p-tau181 and cortical excitability are present in healthy middle-aged subjects and that p-tau181 increases may reflect activity-dependent secretion.
Ayudas:	"la Caixa" Foundation LCF/BQ/DI19/11730050 "la Caixa" Foundation LCF/BQ/DI18/11660026 European Commission 101053962 European Commission 860197 European Commission 713673
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Alzheimer's disease ; Tau ; EEG ; Transcranial magnetic stimulation
Publicado en:	Heliyon, Vol. 10 (december 2024) , ISSN 2405-8440

DOI: 10.1016/j.heliyon.2024.e41118
PMID: 39759333

10 p, 1.2 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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