Current applications, procedural and 1-year outcomes of Rotatripsy for the treatment of calcified coronary lesions
van Oort, M.J.H. (Leiden University Medical Center)
Al Amri, I. (Leiden University Medical Center)
Bingen, B.O. (Leiden University Medical Center)
Oliveri, F. (Leiden University Medical Center)
Vilalta, Victoria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jurado-Román, Alfonso (Hospital Universitario La Paz (Madrid))
Pereira, A.R. (Hospital Universitario La Paz (Madrid))
Cordoba-Soriano, J.G. (Complejo Hospitalario Universitario de Albacete)
Rumiz González, E. (Consorci Hospital General Universitari de Valencia)
Fernández-Peregrina, Estefanía (Institut de Recerca Sant Pau)
van der Kley, F. (Leiden University Medical Center)
Jukema, J.W. (Netherlands Heart Institute)
Montero-Cabezas, J.M. (Leiden University Medical Center)
Universitat Autònoma de Barcelona

Fecha:	2024
Resumen:	Intravascular lithotripsy (IVL) combined with rotational atherectomy (RA), known as Rotatripsy, is used to treat severe coronary artery calcification (CAC), though data on efficacy, midterm safety and use sequence is limited. We aimed to identify indicators for Rotatripsy use and to assess its safety and success rates, both acutely and at 1-year follow-up. Patients undergoing Rotatripsy for severe CAC across six centers from May 2019 to December 2023 were included. Demographic, clinical, procedural and follow-up data were collected. Efficacy endpoints included device success (delivery of the RA-burr and IVL-balloon across the target lesion and administration of therapy without related complications), technical success (TIMI 3 flow and residual stenosis <30% by quantitative coronary analysis) and procedural success [composite of technical success with absence of in-hospital major adverse cardiovascular events (MACE: cardiac death, myocardial infarction or target vessel revascularization). Safety endpoints comprised Rotatripsy-related complications and MACE at 1-year follow-up. A total of 114 patients (75 ± 9 years, 78% male) underwent Rotatripsy for 120 lesions. In the majority of procedures RA was followed by IVL, mostly electively (n = 68, 57%) but also for balloon underexpansion (n = 37, 31%) and stent crossing failure (n = 1, 1%). Diverse and complex target lesions were addressed with an average SYNTAX score of 24. 6 ± 13. 0. Device, technical and procedural success were 97%, 94% and 93%, respectively. Therapy-related complications included two (2%) coronary perforations, one (1%) coronary dissection and one (1%) burr entrapment. At 1-year follow-up(present in 77(67%) patients), MACE occurred in 7(9%) cases. Over a 1-year follow-up period, Rotatripsy was safe and effective, predominantly using RA electively before IVL.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Coronary artery calcification ; Intravascular lithotripsy ; Rotational atherectomy ; Rotatripsy
Publicado en:	Catheterization and Cardiovascular Interventions, Vol. 104 Núm. 2 (january 2024) , p. 203-212, ISSN 1522-726X

DOI: 10.1002/ccd.31140
PMID: 38932584

10 p, 1.4 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
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