Closed-loop oxygen control for critically ill patients-A systematic review and metaanalysis
Mól, Caroline Gomes (Hospital Israelita Albert Einstein (Sao Paolo, Brasil))
da Silva Vieira, Aléxia Gabriela (Hospital Israelita Albert Einstein (Sao Paolo, Brasil))
Schneider Pereira Garcia, Bianca Maria (Hospital Israelita Albert Einstein (Sao Paolo, Brasil))
dos Santos Pereira, Emanuel (Hospital Israelita Albert Einstein (Sao Paolo, Brasil))
Caserta Eid, Raquel Afonso (Hospital Israelita Albert Einstein (Sao Paolo, Brasil))
Schultz, Marcus J. (Medical University Wien)
Pereira Nunes Pinto, Ana Carolina (Institut de Recerca Sant Pau)
Nawa, Ricardo Kenji (Hospital Israelita Albert Einstein (Sao Paolo, Brasil))
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Background The impact of closed-loop control systems to titrate oxygen flow in critically ill patients, including their effectiveness, efficacy, workload and safety, remains unclear. This systematic review investigated the utilization of closed-loop oxygen systems for critically ill patients in comparison to manual oxygen titration systems focusing on these topics. Methods and findings A search was conducted across several databases including MEDLINE, CENTRAL, EMBASE, LILACS, CINAHL, LOVE, ClinicalTrials. gov, and the World Health Organization on March 3, 2022, with subsequent updates made on June 27, 2023. Evidence databases were searched for randomized clinical parallel or crossover studies investigating closedloop oxygen control systems for critically ill patients. This systematic review and meta-analysis was performed following the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines. The analysis was conducted using Review Manager software, adopting the mean difference or standardized mean difference with a 95% confidence interval (95% CI) for continuous variables or risk ratio with 95% CI for dichotomous outcomes. The main outcome of interest was the percentage of time spent in the peripheral arterial oxygen saturation target. Secondary outcomes included time for supplemental oxygen weaning, length of stay, mortality, costs, adverse events, and workload of healthcare professional. A total of 37 records from 21 studies were included in this review with a total of 1,577 participants. Compared with manual oxygen titration, closed-loop oxygen control systems increased the percentage of time in the prescribed SpO2 target, mean difference (MD) 25. 47; 95% CI 19. 7, 30. 0], with moderate certainty of evidence. Current evidence also shows that closed-loop oxygen control systems have the potential to reduce the percentage of time with hypoxemia (MD -0. 98; 95% CI -1. 68, -0. 27) and healthcare workload (MD -4. 94; 95% CI -7. 28, -2. 61) with low certainty of evidence. Conclusion Closed-loop oxygen control systems increase the percentage of time in the preferred SpO2 targets and may reduce healthcare workload.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Critical Illness ; Humans ; Oxygen ; Oxygen Inhalation Therapy ; Oxygen Saturation
Published in:	PloS one, Vol. 19 Núm. 6 June (june 2024) , p. e0304745, ISSN 1932-6203

DOI: 10.1371/journal.pone.0304745
PMID: 38865428

21 p, 2.7 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles