Pertussis Outbreak During 2023 in Gipuzkoa, North Spain
Marimón, José María (Hospital de Donostia (Sant Sebastià, País Basc))
Montes, Milagrosa (Hospital de Donostia (Sant Sebastià, País Basc))
Vizuete, Nahikari (Hospital de Donostia (Sant Sebastià, País Basc))
Alvarez Guerrico, Lorea (Gobierno Vasco. Departamento de Salud. Subdireccion de Salud Publica y Adicciones-Gipuzkoa)
Aginagalde, Adrian Hugo (Biogipuzkoa Health Research Institute)
Mir-Cros, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
González-López, Juanjo 1975- (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Vicente, Diego (Universidad del País Vasco)

Data:	2024
Resum:	Background: Pertussis has re-emerged in many countries despite the wide use of vaccines for over 60 years. During 2023, we observed an increase in the incidence of pertussis in Gipuzkoa, north of Spain (with a population of 657,140 inhabitants), mainly affecting children between 11 and 15 years of age. Methods: This study included all confirmed cases diagnosed by PCR in nasopharyngeal swab samples. The genome of seven isolates collected in 2023 was sequenced. Results: Between 2018 and 2023, 884 cases of whooping cough were diagnosed. Pertussis incidence (in cases per 100,000 inhabitants) decreased from 36. 7 in 2018 to no cases in 2021, increasing again to 56. 8 in 2023. In 2023, the age group of 11-15 years old had the highest incidence rate of 409. 3. Only 2 of the 56 children < 6 years old required hospitalization, and there were no deaths. The seven isolates collected in 2023 showed the same BPagST-4 (ptxA1/ptxP3/prn2/fim2-1/fim3 -1 allelic combination), with all of them expressing the pertactin antigen. Conclusions: Immunity waning after the last dose of vaccination at 6 years old, together with the lack of circulation of Bordetella pertussis during the COVID-19 pandemic, were probably the main reasons for the high increase in the incidence of pertussis in Gipuzkoa in 2023.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bordetella pertussis ; Vaccination ; Outbreak
Publicat a:	Vaccines (Basel), Vol. 12 (october 2024) , ISSN 2076-393X

DOI: 10.3390/vaccines12101192
PMID: 39460357

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