Clinical recognition of frontotemporal dementia with right anterior temporal predominance : A multicenter retrospective cohort study
Ulugut, H. (University of California)
Bertoux, M. (Université de Lille)
Younes, K. (Stanford University)
Montembeault, M. (McGill University)
Fumagalli, G.G. (Università degli Studi di Trent)
Samanci, B. (Istanbul University)
Illán-Gala, Ignacio (Institut de Recerca Sant Pau)
Kuchcinski, G. (Université de Lille)
Leroy, M. (Université de Lille)
Thompson, J.C. (University of Manchester)
Kobylecki, C. (University of Manchester)
Santillo, A.F. (Lund University)
Englund, E. (Lund University)
Waldö, M.L. (Lund University)
Riedl, L. (Technical University of Munich)
Van den Stock, J. (Leuven Brain Institute)
Vandenbulcke, M. (Leuven Brain Institute)
Vandenberghe, R. (University Hospital Leuven)
Laforce, Robert Jr (Laval University)
Ducharme, S. (McGill University)
Pressman, P.S. (University of Colorado)
Caramelli, P. (Universidade Federal de Minas Gerais)
de Souza, L.C. (Universidade Federal de Minas Gerais)
Takada, L.T. (University of São Paulo Medical School)
Gurvit, H. (Istanbul University)
Hansson, Oskar (Lund University)
Diehl-Schmid, J. (Kbo-Inn-Salzach-Klinikum)
Galimberti, D. (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Pasquier, F. (Université de Lille)
Miller, B.L. (University of California)
Scheltens, P. (Vrije Universiteit Amsterdam)
Ossenkoppele, R. (Amsterdam University Medical Center (UMC))
van der Flier, W.M. (Alzheimer Center Amsterdam)
Barkhof, Frederik (University College London)
Fox, N.C. (UCL Institute of Neurology (Regne Unit))
Sturm, V.E. (University of California)
Miyagawa, T. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Whitwell, J.L. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Boeve, B. (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Rohrer, J.D. (UCL Institute of Neurology (Regne Unit))
Gorno-Tempini, M.L. (University of California)
Josephs, Keith A (Mayo Clinic (Rochester, Estats Units d'Amèrica))
Snowden, J. (University of Manchester)
Warren, J.D. (UCL Institute of Neurology (Regne Unit))
Rankin, K.P. (University of California)
Pijnenburg, Y.A.L. (Alzheimer Center Amsterdam)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Although frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype. Retrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments. Common symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word-finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face-recognition deficits (60%). Real-life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations. This study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real-life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients. Highlights: This project is the first international collaboration and largest reported cohort. Further efforts are warranted for precise nomenclature reflecting neural mechanisms. Our results will serve as a clinical guideline for early and accurate diagnoses.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Emotion recognition ; Frontotemporal dementia ; Frontotemporal lobar degeneration ; Right anterior temporal lobe ; Semantic dementia ; Social cognition
Published in:	Alzheimer's & dementia, Vol. 20 Núm. 8 (august 2024) , p. 5647-5661, ISSN 1552-5279

DOI: 10.1002/alz.14076
PMID: 38982845

15 p, 697.6 KB

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