Novel In Silico Strategies to Model the In Vivo Nerve Scarring Around Implanted Parylene C Devices
Sergi, Pier Nicola (Sant'Anna School of Advanced Studies. The BioRobotics Institute and Department of Excellence in Robotics and Artificial Intelligence)
Del Valle, Jaume (Universitat de Barcelona. Departament de Bioquímica i Fisiologia)
Stieglitz, Thomas (Laboratory for Biomedical Microtechnology. Department of Microsystems Engineering)
Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Micera, Silvestro (Ecole Polytechnique Federale de Lausanne)
Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia

Fecha:	2024
Resumen:	The implantation of materials into in vivo peripheral nerves triggers the production of scar tissue. A scar capsule progressively incorporates foreign bodies, which become insulated from the surrounding environment. This phenomenon is particularly detrimental in the case of electrical active sites enveloped within scar sheets, since the loss of contact with axons highly decreases the effectiveness of neural interfaces. As a consequence, the in silico modelling of scar capsule evolution may lead to improvements in the design of intraneural structures and enhancing their reliability over time. In this work, a novel theoretical framework is proposed to model the evolution of capsule thickness over time together with an improved optimisation procedure able to avoid apparently suitable choices resulting from standard procedures. This framework provides a fast, simple, and accurate modelling of experimental data ((Formula presented. )), definitely improving on previous approaches.
Ayudas:	European Commission 101099366
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Neural implants ; Foreign body reaction ; Scar tissue ; Peripheral nerves
Publicado en:	Applied sciences (Basel), Vol. 14, Issue 22 (November 2024) , art. 10741, ISSN 2076-3417

DOI: 10.3390/app142210741

23 p, 2.9 MB

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