Dietary Inulin Supplementation Modulates Fecal Microbiota and Vaccine Response in Cats-A Double-Blind Randomized Controlled Pilot Study
Jeusette, Isabelle (Affinity Petcare)
Apper, Emmanuelle (Affinity Petcare)
Meli, Marina (University of Zurich. Department of Clinical Diagnostics and Services)
Hofmann-Lehmann, Regina (University of Zurich. Department of Clinical Diagnostics and Services)
Salas-Mani, Anna (Affinity Petcare)
Fernández-Pinteño, Anna (Affinity Petcare)
Francino, Olga (Universitat Autònoma de Barcelona. Servei Veterinari de Genètica Molecular)
Torre, Celina (Affinity Petcare)

Data:	2024
Resum:	Twenty-six cats were fed either a control or an inulin-supplemented diet (0. 6%) for six weeks with measurements of fecal short-chain fatty acids (SCFAs) and microbiota. In the second phase, cats were fed their respective diets for another six weeks and were then primo-vaccinated against the feline leukemia virus (FeLV) at days 0 and 21. Serum anti-FeLV IgG responses were monitored. Compared to the control group, the inulin group exhibited higher Firmicutes (+14%) and lower Bacteroidetes (-56%) and Prevotellaceae (-51%) after six weeks of supplementation. Compared to T0, SCFAs initially decreased at week 3 but subsequently increased at week 6 with inulin supplementation, leading to higher butyrate compared to the control group at week 6. A significant diet-by-time interaction was also observed for propionate and total SCFAs. Compared to the control group, the inulin group tended to show a higher serum anti-FeLV IgG response after the first vaccination (p = 0. 09), with significant differences at days 5 and 11 post-vaccination. These preliminary results suggest that a six-week dietary supplementation with a low dose of inulin in cats can modify the fecal microbiota and its functional metabolites, potentially influencing the early immune response to vaccination.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Inulin ; Fecal microbiota ; Prebiotic ; Immune response ; Fructans ; Short-chain fatty acids
Publicat a:	Pets, Vol. 1 Núm. 3 (December 2024) , p. 485-499, ISSN 2813-9372

DOI: 10.3390/pets1030033

15 p, 1.9 MB

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