Towards the development of a portable device based on modified-voltammetric sensors for the detection of illicit drugs and seized samples
Cetó Alsedà, Xavier (Universitat Autònoma de Barcelona. Departament de Química)
Truta, Florina Maria (Iuliu Hațieganu University of Medicine and Pharmacy)
Drăgan, Ana-Maria (Iuliu Hațieganu University of Medicine and Pharmacy)
Rodríguez-Franch, Elena (Universitat Autònoma de Barcelona. Departament de Química)
Tertis, Mihaela (Iuliu Hațieganu University of Medicine and Pharmacy)
Sánchez-Pereña, Ángela (Policia de la Generalitat-Mossos d'Esquadra. Divisió de Policia Científica)
Comellas-Tena, Sara (Policia de la Generalitat-Mossos d'Esquadra. Divisió de Policia Científica)
Cristea, Cecilia (Iuliu Hațieganu University of Medicine and Pharmacy)
Valle Zafra, Manuel del (Universitat Autònoma de Barcelona. Departament de Química)

Data:	2025
Resum:	Illicit drugs are a global burden, not only for society, but also for the various control authorities for which its rapid on-site detection remains a challenge. In this context, the potential of a voltammetric electronic tongue (ET) for the analysis of different drugs is evaluated herein. Concretely, the discrimination and identification of cocaine, heroin, 3,4-Methylenedioxymethamphetamine (MDMA), methamphetamine and ketamine in self-prepared and real samples were attempted. For its analysis, an array of three carbon-based screen-printed electrodes (SPE) was prepared, and their responses towards the different drugs and some of the more common cutting agents and adulterants were assessed by means of square wave voltammetry (SWV). To this aim, a tiny amount (ca. 3 mg) of the drug powder was added to the electrochemical cell containing phosphate buffer (pH 12), shaken, and measured directly without any other pre-treatment than its dilution. Next, to identify their characteristic fingerprint, obtained voltammograms were submitted to linear discriminant analysis (LDA), which allowed to correctly identify the different drugs regardless of the presence of the different cutting agents and other possible interfering compounds, or their concentration. Satisfactory results were obtained both for the synthetic and the "street" seized samples, with a classification rate of 100 % for the external test subset of the latter (n = 10).
Ajuts:	European Commission 833787 Agencia Estatal de Investigación PID2022-136709OB
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Electronic tongue ; Voltammetric sensors ; Drugs of abuse ; Seized drugs ; Chemometrics ; Cutting agents
Publicat a:	Talanta, Vol. 282 (January 2025) , art. 127055, ISSN 1873-3573

DOI: 10.1016/j.talanta.2024.127055

7 p, 2.8 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats