Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease
Ben-Aicha Gonzalez, Soumaya (Imperial College London)
Anwar, M. (Imperial College London)
Vilahur, Gemma (Institut de Recerca Sant Pau)
Martino, F. (Imperial College London)
Kyriazis, P.G. (Hammersmith Hospital (Londres))
de Winter, N. (Imperial College London)
Punjabi, P.P. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Angelini, G.D. (University of Bristol)
Sattler, S. (Medical University of Graz)
Emanueli, C. (Imperial College London)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Coronary artery disease (CAD) is a major health issue. This study focused on pericardial macrophages and small extracellular vesicles (sEVs) in CAD. The macrophages in CAD patients showed reduced expression of protective markers and unchanged levels of proinflammatory receptors. Similar changes were observed in buffy-coat-derived macrophages when stimulated with CAD pericardial fluid-derived sEVs. The sEV contained miRNA-6516-5p, which inhibited CD36 and affected macrophage lipid uptake. These findings indicate that sEV-mediated miRNA actions contribute to the decrease in protective pericardial macrophages in CAD.
Grants:	Agencia Estatal de Investigación PID2021-128891OB-I00 Agencia Estatal de Investigación PCI2023-143431 Agencia Estatal de Investigación PLEC2021-007664
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Coronary artery disease ; Macrophages ; Mirnas ; Pericardial fluid ; Small extracellular vesicles
Published in:	JACC: Basic to Translational Science, Vol. 9 Núm. 9 (september 2024) , p. 1057-1072, ISSN 2452-302X

DOI: 10.1016/j.jacbts.2024.05.003
PMID: 39444932

16 p, 3.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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