Understanding Endothelial Dysfunction and Its Role in Ischemic Stroke After the Outbreak of Recanalization Therapies
de la Riva, Pere (Instituto de Salud Carlos III)
Marta-Enguita, J. (Instituto de Salud Carlos III)
Rodríguez Antigüedad, Jon (Institut de Recerca Sant Pau)
Bergareche, A. (Hospital de Donostia (Sant Sebastià, País Basc))
López de Munain, Arantza (Ictus. Biogipuzkoa Institute. Doctor Begiristain sn.)
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Despite recent advances in treatment options, stroke remains a highly prevalent and devastating condition with significant socioeconomic impact. Recanalization therapies, including intravenous thrombolysis and endovascular treatments, have revolutionized stroke management and prognosis, providing a promising framework for exploring new therapeutic strategies. Endothelial dysfunction plays a critical role in the pathophysiology, progression, and prognosis of stroke. This review aims to synthesize the current evidence regarding the involvement of the nitric oxide (NO)/endothelium pathway in ischemic stroke, with a particular focus on aging, response to recanalization therapies, and therapeutic approaches. While significant progress has been made in recent years in understanding the relationship between endothelial dysfunction and stroke, many uncertainties persist, and although treatments targeting this pathway are promising, they have yet to demonstrate clear clinical benefits.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Endothelium ; Nitrous oxide ; Recanalization ; Stroke
Published in:	International journal of molecular sciences, Vol. 25 Núm. 21 (november 2024) , p. 11631, ISSN 1422-0067

DOI: 10.3390/ijms252111631
PMID: 39519182

22 p, 1.7 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles