Soluble fms-like tyrosine kinase to placental growth factor ratio in different stages of early-onset fetal growth restriction and small for gestational age
García Manau, Pablo (Hospital Universitari Vall d'Hebron)
Mendoza, Manel (Hospital Universitari Vall d'Hebron)
Bonacina, Erika (Hospital Universitari Vall d'Hebron)
Garrido-Giménez, Carmen (Hospital Universitari Vall d'Hebron)
Fernández-Oliva, Antonio (Hospital Universitari Vall d'Hebron)
Zanini, Julia (Hospital Universitari Vall d'Hebron)
Catalan, Marina (Hospital Universitari Vall d'Hebron)
Tur, Helena (Hospital Universitari Vall d'Hebron)
Serrano, Berta (Hospital Universitari Vall d'Hebron)
Carreras Moratonas, Elena (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública

Data:	2021
Resum:	Introduction: Increased soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) has been demonstrated in early-onset fetal growth restriction (FGR) and small for gestational age (SGA). sFlt-1/PlGF cut-offs have been described to assess preeclampsia severity; however, sFlt-1/PlGF values present in early-onset SGA and different FGR severity stages remain unknown. Hence, the objective of this study was to describe and compare the sFlt-1/PlGF values and pregnancy outcomes among early-onset SGA/FGR stages. Material and methods: This is a prospective case-control study conducted at Vall d'Hebron University Hospital. Singleton pregnancies with estimated fetal weight <10th centile and a control group of uncomplicated pregnancies between 20 and 31 weeks of gestation were enrolled. Study women were classified at diagnosis into different stages, according to estimated fetal weight centile and Doppler ultrasound. sFlt-1/PlGF serum concentrations were measured at diagnosis and, together with pregnancy outcomes, were compared among FGR severity stages, SGA, and controls. Finally, correlations between sFlt-1/PlGF values and time to delivery, gestational age at delivery, days of neonatal admission, and birthweight z-scores were investigated. Results: Among the 207 women enrolled, 32 (15. 4%) had uncomplicated pregnancies, 49 (23. 7%) pregnancies showed SGA, and 126 (60. 9%) involved FGR (92 being stage I, 17 stage II, and 17 stage III). SGA and controls had similar median sFlt-1/PlGF values (25. 7 vs 27. 1, P.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Adverse pregnancy outcomes ; Angiogenic factors ; FGR ; PlGF ; Sflt-1 ; SGA
Publicat a:	Acta obstetricia et gynecologica Scandinavica, Vol. 100 Núm. 1 (january 2021) , p. 119-128, ISSN 1600-0412

DOI: 10.1111/aogs.13978

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