Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia
Pujol Nuez, Jesús (Institut Hospital del Mar d'Investigacions Mèdiques)
Pujol, Nuria (Institut Hospital del Mar d'Investigacions Mèdiques)
Mané, Anna (Institut Hospital del Mar d'Investigacions Mèdiques)
Martinez Vilavella, Gerard (Hospital del Mar (Barcelona, Catalunya))
Deus Yela, Juan (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Pérez Solà, Víctor (Institut Hospital del Mar d'Investigacions Mèdiques)
Blanco Hinojo, Laura, 1981- (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2023
Resum:	Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia. GABA interneuron deficiency is locally expressed in the form of neural activity desynchronization. We mapped the functional anatomy of local synchrony in the cerebral cortex in schizophrenia using functional connectivity MRI. Data from 86 patients with schizophrenia and 137 control subjects were obtained from publicly available repositories. Resting-state functional connectivity maps based on Iso-Distant Average Correlation measures across three distances were estimated detailing the local functional structure of the cerebral cortex. Patients with schizophrenia showed weaker local functional connectivity (i. e. , lower MRI signal synchrony) in (i) prefrontal lobe areas, (ii) somatosensory, auditory, visual, and motor cortices, (iii) paralimbic system at the anterior insula and anterior cingulate cortex, and (iv) hippocampus. The distribution of the defect in cortical area synchrony largely coincided with the synchronization effect of the GABA agonist alprazolam previously observed using identical functional connectivity measures. There was also a notable resemblance between the anatomy of our findings and cortical areas showing higher density of parvalbumin (prefrontal lobe and sensory cortices) and somatostatin (anterior insula and anterior cingulate cortex) GABA interneurons in humans. Our results thus provide detail of the functional anatomy of synchrony changes in the cerebral cortex in schizophrenia and suggest which elements of the interneuron system are affected. Such information could ultimately be relevant in the search for specific treatments.
Nota:	Altres ajuts: NIMH cooperative agreement (1U01 MH097435); Consortium for Neuropsychiatric Phenomics (UL1-DE019580)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Functional connectivity ; Gamma-aminobutyric acid ; Parvalbumin ; Psychosis ; Somatostatin
Publicat a:	European psychiatry, Vol. 66, Núm. 1 (October 2023) , ISSN 1778-3585

DOI: 10.1192/j.eurpsy.2023.2463
PMID: 37848404

8 p, 1.7 MB

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