Tracking temporal response dynamics in the ventral striatum during social feedback in anorexia nervosa : A functional magnetic resonance imaging exploratory study
Membrives, Sonia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
López-Solà, Marina (Universitat de Barcelona)
Fernández Aranda, Fernando (Institut d'Investigació Biomèdica de Bellvitge)
Sánchez, Isabel (Institut d'Investigació Biomèdica de Bellvitge)
Martínez-Zalacaín, Ignacio (Institut d'Investigació Biomèdica de Bellvitge)
Palao, Diego (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Pujol, Jesus (Hospital del Mar (Barcelona, Catalunya))
Menchón Magriñá, José Manuel (Institut d'Investigació Biomèdica de Bellvitge)
Davey, Chris G. (The University of Melbourne)
Harrison, Ben J. (The University of Melbourne)
Keating, Charlotte (Swinburne University of Technology)
Rossell, Susan L. (Swinburne University of Technology)
Oliva, Joan Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Cardoner, N. (Narcís) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Via, Esther (Hospital Sant Joan de Déu (Barcelona, Catalunya))

Date:	2021
Abstract:	Objective: Research suggests abnormalities in reward-based processes in anorexia nervosa (AN). However, few studies have explored if such alterations might be associated with different temporal activation patterns. This study aims to characterize alterations in time-dependent processes in the ventral striatum (VS) during social feedback in AN using functional magnetic resonance imaging (fMRI). Method: Twenty women with restrictive-subtype AN and 20 age-matched healthy controls (HC) underwent a social judgment experimental fMRI task. Temporal VS hemodynamic responses were extracted in SPM for each participant and each social condition (acceptance/rejection). Results: Compared with age-matched HC, patients with AN showed a significant time by group interaction of peak VS response throughout the task, with a progressive blunting of peak activation responses, accompanied by a progressive increase in baseline activity levels over time. Discussion: The results suggest an attenuated response pattern to repetitive social rejection in the VS in patients with AN, together with a difficulty in returning to baseline. The information obtained from this study will guide future, design-specific studies to further explore alterations temporal dynamics.
Grants:	Instituto de Salud Carlos III PI17/01167 Instituto de Salud Carlos III PI20/00132
Rights:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anorexia nervosa ; Functional magnetic resonance imaging ; Reward system ; Social reward ; Ventral striatum
Published in:	International Journal of Eating Disorders, Vol. 54 Núm. 10 (October 2021) , p. 1881-1886, ISSN 1098-108X

DOI: 10.1002/eat.23604

Postprint 15 p, 659.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles