Increased Risk of Myositis-Specific and Myositis-Associated Autoantibodies After COVID-19 Pandemic and Vaccination : A Spanish Multicenter Collaborative Study
García-Bravo, Laura (Hospital Clínico San Carlos (Madrid))
Prada, Alvaro (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Gutiérrez Larrañaga, María (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Espinosa Ros, Eduardo (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Almeida González, Delia (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Martín Martínez, Dolores (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Rodríguez Sánchez, Telesforo (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Mingorance Gámez, Carlos Gustavo (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Jurado Roger, Aurora (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Aguado Álvarez, Rocío (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Díaz Luna, María De Las Mercedes (Hospital General Universitario Gregorio Marañón)
Rodríguez Hernández, Carmen (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
de la Varga-Martínez, Raquel (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
López-Cueto, María (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Julià Benique, María Rosa (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
San José-Cascón, Miriam (Institut Germans Trias i Pujol)
Quirant, Bibiana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez-Chamorro, Alba (Complejo Hospitalario de Jaén)
Marcaida-Benito, Goitzane (Hospital General Universitario de Valencia)
Timoneda Timoneda, Pilar Teresa (Hospital General Universitario de Valencia)
Fandos Sánchez, Marta (Hospital General Universitario de Valencia)
Sacristán Enciso, Beatriz (Hospital de Mérida)
Mohamed Mohamed, Kauzar (Hospital Clínico San Carlos (Madrid))
Guerra-Galán, Teresa (Hospital Clínico San Carlos (Madrid))
Villegas, Ángela (Hospital Clínico San Carlos (Madrid))
Roncancio-Clavijo, Andrés (Hospital Clínico San Carlos (Madrid))
Rodríguez-Mahou, Margarita (Hospital General Universitario Gregorio Marañón)
Sánchez-Ramón, Silvia (Hospital General Universitario Gregorio Marañón)
Fernández-Arquero, Miguel (Hospital Clínico San Carlos (Madrid))
Candelas-Rodríguez, Gloria (Hospital Clínico San Carlos (Madrid))
Ochoa-Grullón, Juliana (Hospital Clínico San Carlos (Madrid))

Data:	2024
Resum:	Background: Emerging evidence suggests that SARS-CoV-2 infection and vaccines may trigger autoimmune responses in predisposed individuals. Idiopathic inflammatory myopathies (IIMs) are diseases with diverse clinical manifestations, often associated with myositis autoantibodies (MAs). Diagnosing IIM is challenging due to limitations in classification criteria and diagnostic assays. This study aimed to describe the incidence of IIM following SARS-CoV-2 infection or vaccination and compare rates between exposures. Methods: A multicenter observational study was conducted with 788 patients from 11 Spanish referral centers. A total of 1209 autoantibodies including myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs), were analyzed using line blot immunoassay (LIA). Results: The study identified distinct patterns in aminoacyl-tRNA synthetase (ARS) antibody frequencies compared to pre-pandemic periods. Anti-PL-7 was the most prevalent ARS antibody (14. 85%), while anti-Jo-1 was less frequent (7. 23%). Anti-MDA5, commonly linked to SARS-CoV-2 infection, was detected in 11. 68%. ANA positivity was observed in 60. 66%, suggesting an autoimmune background. The most frequent diagnoses were anti-synthetase syndrome (ASSD) or IIM-non-ASSD (21. 31%), followed by other systemic autoimmune diseases (SAIDs) (13. 57%). Among the cohort, 91. 13% received at least one dose of a messenger RNA (mRNA) COVID-19 vaccine, with a median of three doses per patient. Patients with prior SARS-CoV-2 infection or heterologous vaccination showed a higher frequency of multiple autoantibody positivity (p < 0. 05), reflecting distinct immune signatures. Conclusions: This study provides valuable insights into the autoimmune risks and phenotypes associated with SARS-CoV-2 infection and vaccination, establishing a basis for further research on IIM and its link to MSAs and MAAs.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Myositis autoantibodies ; Idiopathic inflammatory myopathies ; Anti-synthetase syndrome ; Anti-aminoacyl-trna synthetase autoantibodies ; Line blot immunoassays ; Coronavirus disease 2019 ; SARS-CoV-2 infection ; COVID-19 vaccine ; Mrna vaccine
Publicat a:	Biomedicines, Vol. 12 Núm. 12 (December 2024) , ISSN 2227-9059

DOI: 10.3390/biomedicines12122800
PMID: 39767707

17 p, 2.5 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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