SYNERGY-Everolimus-Eluting Stent With a Bioabsorbable Polymer in ST-Elevation Myocardial Infarction : CLEAR SYNERGY OASIS-9 Registry
Jolly, Sanjit (Population Health Research Institute McMaster University (Hamilton, Canadà))
Lee, Shun F. (Population Health Research Institute McMaster University (Hamilton, Canadà))
Mian, Raul (Population Health Research Institute McMaster University (Hamilton, Canadà))
Kedev, Sasko (University Ss. Cyril and Methodius (Skopje, Macedònia del Nord))
Lavi, Shahar (Western University (London, Canadà))
Moreno, Raul (Hospital Universitario La Paz (Madrid))
Montalescot, Gilles (Hôpital Pitié-Salpêtrière (Paris, França))
Hillani, Ali (Dalhousie University (Halifax, Canadà))
Henry, Timothy D. (The Christ Hospital Health Network (Cincinnati, Estats Units d'Amèrica))
Asani, Valon (Clinical Hospital Tetovo (Macedònia))
Storey, Robert F. (University of Sheffield (Regne Unit))
Silvain, Johanne (Hôpital Pitié-Salpêtrière (Paris, França))
Spratt, James C.S. (George's University of London (Regne Unit))
d'Entremont, Marc-André (Centre Hospitalier Universitaire de Sherbrooke (Quebec, Canadà))
Stankovic, Goran (University Clinical Center of Serbia)
Zafirovska, Biljana (University Ss. Cyril and Methodius (Skopje, Macedònia del Nord))
Natarajan, Madhu k (Population Health Research Institute McMaster University (Hamilton, Canadà))
Sabaté Tenas, Manel (Hospital Clínic i Provincial de Barcelona)
Shreenivas, Satya (The Christ Hospital Health Network ( Cincinnati, Estats Units d'Amèrica))
Pinilla-Echeverri, Natalia (Population Health Research Institute McMaster University (Hamilton, Canadà))
Sheth, Tej (Population Health Research Institute McMaster University (Hamilton, Canadà))
Abdul-Jawad Altisent, Omar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ribas Barquet, Núria (Hospital del Mar (Barcelona, Catalunya))
Skuriat, Elisabeth (Population Health Research Institute McMaster University (Hamilton, Canadà))
Tyrwhitt, Jessica (Population Health Research Institute McMaster University (Hamilton, Canadà))
Mehta, Shamir R. (Population Health Research Institute McMaster University (Hamilton, Canadà))
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Our objective was to evaluate the clinical effectiveness of the SYNERGY stent (Boston Scientific Corporation, Marlborough, Massachusetts) in patients with ST-elevation myocardial infarction (STEMI). The only drug-eluting stent approved for treatment of STEMI by the Food and Drug Administration is the Taxus stent (Boston Scientific) which is no longer commercially available, so further data are needed. The CLEAR (Colchicine and spironolactone in patients with myocardial infarction) SYNERGY stent registry was embedded into a larger randomized trial of patients with STEMI (n = 7,000), comparing colchicine versus placebo and spironolactone versus placebo. The primary outcome for the SYNERGY stent registry is major adverse cardiac events (MACE) as defined by cardiovascular death, recurrent MI, or unplanned ischemia-driven target vessel revascularization within 12 months. We estimated a MACE rate of 6. 3% at 12 months after primary percutaneous coronary intervention for STEMI based on the Thrombectomy vs percutaneous coronary intervention alone in STEMI (TOTAL) trial. Success was defined as upper bound of confidence interval (CI) to be less than the performance goal of 9. 45%. Overall, 733 patients were enrolled from 8 countries with a mean age 60 years, 19. 4% diabetes mellitus, 41. 3% anterior MI, and median door-to-balloon time of 72 minutes. The MACE rate was 4. 8% (95% CI 3. 2 to 6. 3%) at 12 months which met the success criteria against performance goal of 9. 45%. The rates of cardiovascular death, recurrent MI, or target vessel revascularization were 2. 7%, 1. 9%, 1. 0%, respectively. The rates of acute definite stent thrombosis were 0. 3%, subacute 0. 4%, late 0. 4%, and cumulative stent thrombosis of 1. 1% at 12 months. In conclusion, the SYNERGY stent in STEMI performed well and was successful compared with the performance goal based on previous trials.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	PCI ; STEMI ; Drug-eluting stent
Published in:	American Journal of Cardiology, Vol. 220 (june 2024) , p. 111-117, ISSN 1879-1913

DOI: 10.1016/j.amjcard.2024.02.021
PMID: 38447893

7 p, 990.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles