Association between N-terminal pro-brain natriuretic peptide and maximal functional capacity in heart failure with preserved ejection fraction : The modifying role of obesity
Palau, Palau (Universitat de València)
Núñez, Gonzalo (Universitat de València)
De la Espriella, Rafael (Universitat de València)
Miñana, Gema (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Domínguez, Eloy (Universitat Jaume I)
Lorenzo, Miguel (Universitat de València)
López, Laura (Universitat de València)
Flor, Cristina (Universitat de València)
Marín, Paloma (Universitat de València)
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Sanchis, Juan (Universitat de València)
Núñez, Julio (Universitat de València)

Date:	2024
Abstract:	This study investigates the association between maximal functional capacity (peakVO) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in 133 ambulatory patients with heart failure with preserved ejection fraction (HFpEF), focusing on patients with obesity. Across all participants, NT-proBNP inversely correlated with peakVO. However, this association varied based on obesity status. In patients without obesity, there was an inverse relationship between NT-proBNP and peakVO, while no significant correlation was observed in patients with obesity. These findings suggest that in stable ambulatory HFpEF, NT-proBNP did not predict peakVO in patients with obesity.
Grants:	Instituto de Salud Carlos III PI17/01426
Note:	This work was supported by grants from the Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute (PI17/01426) and co-funded with EDRF Funds and CIBER Cardiovascular Funds (16/11/00420 and 16/11/00403).
Note:	This work was supported by grants from the Spanish Ministry of Economy and Competitiveness through the Carlos III Health Institute: FIS (PI17/01426) and co-funded with EDRF funds and CIBER Cardiovascular funds (16/11/00420 and 16/11/00403).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Obesity Research and Clinical Practice, Vol. 18 Núm. 3 (january 2024) , p. 226-231, ISSN 1878-0318

DOI: 10.1016/j.orcp.2024.05.005

6 p, 2.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles