Clinical results after external reinforcement of colorectal anastomosis : a systematic review
Gené Škrabec, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cremades, Manel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernández-Pujol, Andrea (King's College London)
Cortinovis, Sara (Università degli studi di Trieste)
Corral, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Julián, Joan F. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Parés, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona. Departament de Cirurgia

Data:	2023
Resum:	OBJECTIVE: The aim of this review is to describe and assess the existing methods to cover colorectal anastomoses with biomaterials and their clinical impact in reducing anastomotic leakage (AL). SUMMARY BACKGROUND DATA: The most serious complication in colorectal surgery is AL. Despite improvements in its diagnosis and management, AL remains an unresolved issue. To prevent its appearance and clinical consequences, different external reinforcement techniques with synthetic or biomaterials have been described. METHODS: A systematic review search of the available literature until June 2022 was performed, looking for all literature regarding external reinforcement of colonic or colorectal anastomoses. After the review process, a classification of materials was proposed into solid and liquid materials, and an assessment of their clinical impact was performed. The study protocol has been registered at PROSPERO and has been reported in the line with PRISMA and AMSTAR Guidelines 11,12. RESULTS: Ninety-seven articles that fulfilled inclusion criteria, were identified and revised. Overall, 18 of the selected articles focused on human clinical trials and 79 on animal models. Only fibrin sealants, collagen patches, and omentoplasty have shown positive results in humans. CONCLUSIONS: Fibrin sealants, collagen patches, and omentoplasty are, so far, the most studied biomaterials. However, further studies are required to confirm these findings before definite recommendations can be made.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Anastomotic Leak ; External coating ; Sealant
Publicat a:	International journal of surgery, Vol. 109 Núm. 12 (December 2023) , p. 4322-4332, ISSN 1743-9159

DOI: 10.1097/JS9.0000000000000747
PMID: 37707516

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El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Articles de recerca
Articles > Articles publicats