Diabetes Mellitus in Kidney Transplant Recipients : New Horizons in Treatment
Sánchez-Baya, Maya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bolufer, Mónica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Massó, Elisabet (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Paul, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Coll-Brito, Veronica (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Taco, Omar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Anton-Pampols, Paula (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gelpi, Rosana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
DaSilva Santos, Iara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Casas, Ángela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rodríguez, Rosely (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Molina, María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cañas, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vila, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ara del Rey, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Date:	2025
Abstract:	Diabetes mellitus (DM) in kidney transplant recipients (KTR) is a risk factor for mortality, increases the risk of infections and, in the long term, can lead to graft loss due to diabetic kidney disease. A preventive approach applied to those on the waiting list could decrease the incidence of post-transplant DM (PTDM) by detecting those patients at risk, thus allowing strategies to minimize the probability of developing a New Onset Diabetes After Transplant (NODAT). On the other hand, modifications of immunosuppressive therapy may improve glucose control in patients with KTR. In recent years, two new classes of antidiabetic drugs and non-steroidal mineralocorticoid receptor antagonists have demonstrated cardiovascular and renal benefits in randomized clinical trials where the transplant population has not been represented. Because of the potential benefit expected in this population, the clinical use of glucagon-like peptide-1 receptor agonists (GLP-1RA), sodium-glucose cotransporter 2 inhibitors (SGLT2i) and finerenone is increasing in the kidney transplant setting. This review focuses on comprehensive pharmacological interventions in KTR with glucose metabolism disorders. In-depth knowledge in this area will allow prevention and identification of potential adverse effects or drug interactions in the clinical course of KTR with DM.
Grants:	Instituto de Salud Carlos III RICORS2040 European Commission RICORS2040
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Post-transplant diabetes mellitus ; Diabetes mellitus ; Cardiovascular disease
Published in:	Journal of clinical medicine, Vol. 14 (february 2025) , ISSN 2077-0383

DOI: 10.3390/jcm14041048
PMID: 40004579

13 p, 276.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles