Treatment of bacterial sexually transmitted infections in Europe : gonorrhoea, Mycoplasma genitalium, and syphilis
Mitjà, Oriol (Universitat Autònoma de Barcelona)
Suñer, Clara (Universitat Autònoma de Barcelona)
Giacani, Lorenzo (University of Washington (Seattle, Estats Units d'Amèrica))
Vall-Mayans, Martí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Tiplica, George-Sorin (Carol Davila University of Medicine and Pharmacy (Bucharest, Rumania))
Ross, Jonathan D.C. (University Hospitals Birmingham NHS Foundation Trust (Birmingham, Estats Units d'Amèrica))
Bradshaw, Catriona S. (Monash University (Melbourne, Austràlia))

Date:	2023
Abstract:	This review explores the therapeutic challenges of sexually transmitted infections (STI) in Europe, which include increasing antimicrobial resistance and limited progress in drug discovery. We primarily focus on gonorrhoea, Mycoplasma genitalium, and syphilis infections. For gonorrhoea with escalating resistance rates we explore the possibility of combining ceftriaxone with another antibiotic or using alternative antibiotics to mitigate resistance emergence, and we provide insights on the ongoing evaluation of new antimicrobials, like gepotidacin and zoliflodacin. In the case of M. genitalium, which exhibits high resistance rates to first and second-line treatments, we emphasize the importance of resistance-guided therapy in regions with elevated resistance levels, and highlight the limited alternative options, such as pristinamycin and minocycline. Furthermore, we address the challenges posed by syphilis, where the primary treatment consists of penicillin or doxycycline, with challenges arising in neurosyphilis, allergy, pregnancy, and supply shortages and discuss the ongoing evaluation of alternative antimicrobials (e. g. , ceftriaxone, cefixime, linezolid). Our findings identify priority actions and provide concrete solutions for long-term effective management of STIs and antimicrobial resistance mitigation.
Grants:	European Commission 850450
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Gonorrhoea ; Mycoplasma ; Syphilis ; Treatment
Published in:	The Lancet Regional Health - Europe, Vol. 34 (october 2023) , ISSN 2666-7762

DOI: 10.1016/j.lanepe.2023.100737
PMID: 37927440

15 p, 997.9 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles