Sex-related differences in severe native valvular heart disease : the ESC-EORP Valvular Heart Disease II survey
Mascherbauer, J. (Department of Internal Medicine 3. University Hospital St. Pölten. Karl Landsteiner University of Health Sciences)
Kammerlander, A. (Department of Internal Medicine 2. Division of Cardiology. Medical University of Vienna)
Nitsche, C. (Department of Internal Medicine 2. Division of Cardiology. Medical University of Vienna)
Bax, J. (Leiden University Medical Center)
Delgado, Victoria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Evangelista Masip, Arturo (Hospital Universitari Vall d'Hebron)
Laroche, C. (EURObservational Research Programme. European Society of Cardiology)
Maggioni, A.P. (ANMCO Research Center. Heart Care Foundation)
Magne, J. (Department of Cardiology. Dupuytren University Hospital 2)
Vahanian, A. (Université Paris-Cité)
Iung, B. (Bichat Hospital. APHP. INSERM LVTS 1148. Université Paris-Cité)
Zera, E.
Shirka, E.
Dado, E.
Heger, M.
Samadov, F.
Rustamova, Y.
Van Camp, G.
Pasquet, A.
Van de Veire, N.
Cosyns, B.
Sindelarova, S.
Linhartova, K.
Ihlemann, N.
Ali, H.H.
Hassan, M.
Ahmed, Y.A.A.
Sadek, Y.
Abdelhamid, M.
Ghareeb, H.S.
Kazamel, G.
Kylmälä, M.M.
Turpeinen, A.
Saraste, A.
Tribouilloy, C.
Biere, L.
Audonnet, M.
Bardet, H.
Marechaux, S.
Habib, G.
Thuny, F.
Monin, J.L.
Donal, E.
Gervais, R.
Bauer, F.
Attias, D.
Daudin, M.
Bernard, A.
Kostovska, E.S.
Radovikj, M.G.
Scholtz, W.
Nickenig, G.
Rassaf, T.
Lehnert, K.
Er, F.
Schulze, P.C.
Akin, I.
Maier, L.S.
Ince, H.
Vorpahl, M.
Sigusch, H.
Rahman Haley, S.L.
Kanakakis, I.
Katsaros, A.
Spargias, K.
Lampropoulos, K.
Bellos, V.
Papafaklis, M.
Makris, A.
Kamperidis, V.
Ninios, V.
Sachpekidis, V.
Poulimenos, L.
Borsányi, T.
Jarai, Z.
Zsáry, A.
Bajraktari, G.
Sime, I.
Erglis, A.
Rancane, G.
Mizariene, V.
Radauskaitė, G.
Demarco, D.C.
Mizia-Stec, K.
Szymanski, P.
Joao, I.
Antunes, N.
Bento, D.
Cardoso, G.
Galrinho, A.
Sousa, C.
Cabral, S.
Carvalho, S.S.
Almeida, I.
Pop, C.
Tint, D.
Popescu, B.A.
Popescu, A.
Grigorica, L.
Arsenescu-Georgescu, C.
Usurelu, C.
Ionac, A.
Petris, A.O.
Kozmin, D.
Kulumbegov, O.
Spiropulos, N.
Boldyrev, S.
Zotov, A.
Irtyuga, O.
Kuznetsov, D.V.
Nikolic, N.M.
Stojsic-Milosavljevic, A.
Ruzicic, D.
Simkova, I.
Valocik, G.
Studencan, M.
Moral, S.
Molina Mora, M.J.
de la Morena Valenzuela, G.
Gallego, I.M.
Mitroi, C.
Vela, T.A.
González-Gómez, A.
Jimenez, L.C.
Castro, N.
Santos, I.M.
Villegas, D.V.
Payá, R.
Esteban, E.
Iglesia-Carreno, C.
Iglesias, F.C.
Demirtas, A.O.
Taylan, G.
Gudul, N.E.
Mert, K.U.
Mert, G.O.
Dogan, S.M.
Arslan, Ş.
Sayar, N.
Yildirim, T.
Yesilay, A.
Sayin, M.R.
Karabag, T.
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Background and Aims To assess sex differences in disease characteristics and treatment of patients with severe native valvular heart disease (VHD) included in the VHD II EURObservational Research Programme. Methods A total of 5219 patients were enrolled in 208 European and North African centres and followed for 6 months [41. 2% aortic stenosis (AS), 5. 3% aortic regurgitation (AR), 4. 5% mitral stenosis (MS), 21. 3% mitral regurgitation (MR), 2. 7% isolated right-sided VHD, 24. 9% multiple left-sided VHD]. Indications for intervention were considered concordant if corresponding to class I recommendations specified in the 2012 ESC or 2014 AHA/ACC VHD guidelines. Results Overall, women were older, more symptomatic, and presented with a higher EuroSCORE II. Bicuspid aortic valve and AR were more prevalent among men while mitral disease, concomitant tricuspid regurgitation (TR), and AS above age 65 were more prevalent among women. On multivariable regression analysis, concordance with recommended treatment was significantly poorer in women with MS and primary MR (both P <. 001). Age, patient refusal, and decline of symptoms after conservative treatment were reported significantly more often as reasons to withhold the intervention in females. Concomitant tricuspid intervention was performed at a similar rate in both sexes although prevalence of significant TR was significantly higher in women. In-hospital and 6-month survival did not differ between sexes. Conclusions (i) Valvular heart disease subtype varied between sexes; (ii) concordance with recommended intervention for MS and primary MR was significantly lower for women; and (iii) survival of men and women was similar at 6 months.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Sex differences ; Valvular heart disease
Published in:	European heart journal, Vol. 45 Núm. 37 (january 2024) , p. 3818-3833, ISSN 1522-9645

DOI: 10.1093/eurheartj/ehae523
PMID: 39212374

16 p, 695.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles