Evolutionary dynamics of the successful expansion of pandemic Vibrio parahaemolyticus ST3 in Latin America
Campbell, Amy Marie (University of Southampton)
Gavilan, Ronnie G. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Abanto Marin, Michel (Universidad de La Frontera (Xile))
Yang, Chao (Chinese Academy of Sciences)
Hauton, Chris (University of Southampton)
van Aerle, Ronny (Centre for Environment, Fisheries and Aquaculture Science)
Martinez-Urtaza, Jaime (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)

Data:	2024
Resum:	The underlying evolutionary mechanisms driving global expansions of pathogen strains are poorly understood. Vibrio parahaemolyticus is one of only two marine pathogens where variants have emerged in distinct climates globally. The success of a Vibrio parahaemolyticus clone (VpST3) in Latin America- the first spread identified outside its endemic region of tropical Asia- provided an invaluable opportunity to investigate mechanisms of VpST3 expansion into a distinct marine climate. A global collection of VpST3 isolates and novel Latin American isolates were used for evolutionary population genomics, pangenome analysis and combined with oceanic climate data. We found a VpST3 population (LatAm-VpST3) introduced in Latin America well before the emergence of this clone in India, previously considered the onset of the VpST3 epidemic. LatAm-VpST3 underwent successful adaptation to local conditions over its evolutionary divergence from Asian VpST3 isolates, to become dominant in Latin America. Selection signatures were found in genes providing resilience to the distinct marine climate. Core genome mutations and accessory gene presences that promoted survival over long dispersals or increased environmental fitness were associated with environmental conditions. These results provide novel insights into the global expansion of this successful V. parahaemolyticus clone into regions with different climate scenarios. Vibrio parahaemolyticus Sequence Type 3 was first reported in India and expanded globally to areas with distinct climates including Latin America. In this study, the authors investigate the evolutionary mechanisms driving emergence of the strain in Latin America using 280 publicly available genomes and 32 samples newly sequenced in this study.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00526 Agencia Estatal de Investigación PID2021-127107NB-I00 European Commission 101057554
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bacterial genes ; Bacterial infection ; Epidemiology ; Phylogenomics
Publicat a:	Nature communications, Vol. 15 (September 2024) , art. 7828, ISSN 2041-1723

DOI: 10.1038/s41467-024-52159-y
PMID: 39244587

15 p, 2.0 MB

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