Parasympathetic nervous system : A key role in control and mood disorders in patients with asthma
Soto-Retes, Lorena (Institut de Recerca Sant Pau)
Milagro, Javier (Universidad de Zaragoza)
Crespo Lessmann, Astrid (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Curto Sánchez, Elena (Universidad de Salamanca)
Mateus Medina, Éder F. (Institut de Recerca Sant Pau)
Bailón, Raquel (Universidad de Zaragoza)
Gil, Eduardo (Universidad de Zaragoza)
Laguna, Pablo (Universidad de Zaragoza)
Plaza, Vicente (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2024
Resum:	Background: Patients with severe asthma often have uncontrolled disease and experience mood disorders, particularly anxiety and depression. The autonomic nervous system (ANS) plays an important role in asthma, mainly through the parasympathetic ANS system (PANS), which favors bronchoconstriction and mental health status. Objective: To evaluate the role of the activation of the PANS in uncontrolled asthma and related mood disorders. Methods: This was a proof-of-concept cross-sectional study that analyzed demographic and clinical variables reflecting asthma severity and control, lung function, inflammation (from induced sputum), evaluation of quality of life, and the risk for anxiety and depression according to validated questionnaires. The PANS analysis was conducted based on heart rate variability: SD of the difference between consecutive normal-to-normal (NN) intervals (SDNN), root mean square of the successive differences (RMSSD), percentage of consecutive NN intervals (pNN50), total power (TP), and respiratory-related power (Pr). Results: A total of 30 patients with asthma were grouped according to asthma control and the risk for anxiety and depression; 10 patients with uncontrolled asthma compared with the patients with controlled asthma showed significant differences (P <. 05) in SDNN (26. 5 [8. 2] vs 42. 7 [29. 7]), RMSSD (14. 1 [6. 5] vs 24 [20]), pNN50 (0. 6 [1. 5] vs 6. 2 [11. 8]), TP (0. 0005 [0. 00046] vs 0. 0014 [0. 00085]), and Pr (0. 0003 [0. 00025] vs 0. 0007 [0. 00060]) respectively. A total of 13 patients at risk for anxiety and depression compared with the patients without showed reduced values (P <. 05) for SDNN (26. 5 [7. 9] vs 45. 6 [31. 3]), pNN50 (0. 75 [1. 4] to 7. 12 [12. 6]), TP (0. 0005 [0. 00048] to 0. 0012 [0. 0008]), and Pr (0. 0003 [0. 00027] to 0. 0008 [0. 00062]). Conclusion: Our results suggest that PANS activity is depressed in patients with uncontrolled asthma and common mood disorders such as depression and anxiety, and the evaluation of heart rate variability may be a useful means for follow-up of asthma control and related mood disorders.
Drets:	Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Autonomic nervous system ; Uncontrolled asthma ; Severe asthma ; Depression ; Anxiety ; Heart rate variability
Publicat a:	Annals of Allergy, Asthma and Immunology, Vol. 133 Núm. 4 (October 2024) , p. 430-436, ISSN 1534-4436

DOI: 10.1016/j.anai.2024.07.022

Postprint

Disponible a partir de: 2025-10-31

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats