Genetic susceptibility to the environment moderates the impact of childhood experiences on psychotic, depressive, and anxiety dimensions
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Torrecilla Gonzalez, Pilar (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Mas-Bermejo, Patricia (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals)
Papiol, Sergi (Instituto de Salud Carlos III)
Bakermans-Kranenburg, Marian (Instituto Universitário de Ciências Psicológicas, Sociais e da Vida)
van IJzendoorn, Marinus (Erasmus University Rotterdam. Department of Psychology, Education and Child Studies)
Jolicoeur-Martineau, Alexia (Samsung Advanced Institute of Technology)
Kwapil, Thomas (University of Illinois at Urbana-Champaign. Department of Psychology)
Rosa, Araceli (Universitat de Barcelona. Institut de Biomedicina)

Data:	2025
Descripció:	12 pàg.
Resum:	BACKGROUND AND HYPOTHESIS: Gene-by-environment (GxE) studies in psychosis have exclusively focused on negative exposures. However, evidence supports the resilience-enhancing effect of positive factors on psychosis outcome. The Differential Susceptibility (DS) model proposes that common genetic variants may confer not only disproportionate responsiveness to negative environments, but also greater sensitivity to positive, resilience-enhancing conditions. This study is the first to apply the DS model to the expression of subclinical psychosis, employing polygenic risk scores of environmental sensitivity (PRS-ES). PRS-ES were hypothesized to moderate, in a DS manner, associations between childhood adversity and psychosis, affective, and anxiety dimensions in young adults. An exploratory goal examined whether PRS for psychotic-like experiences (PRS-PLE) also showed DS patterns. STUDY DESIGN: PRS, schizotypy, PLE, depression, anxiety, and childhood adversity ratings were obtained for 197 nonclinical young adults. LEGIT software for testing competitive-confirmatory GxE models was employed. STUDY RESULTS: Results largely supported DS: Individuals high on PRS-ES showed increased subclinical psychosis, depression, and anxiety if they had experienced elevated childhood adversity, and lower symptoms if exposed to low levels of adversity as compared with those with low PRS-ES. Similarly, PRS-PLE moderated the effect of adversity on PLE, positive schizotypy, and depression following the DS model, but only PRS-ES moderation on PLE survived statistical correction. CONCLUSIONS: Our results suggest that genetic DS to the environment is relevant to psychosis, depression, and anxiety. Current debates on reconceptualization of genetic "risk" and resilience may benefit from this insight that support optimistic views on preventative efforts for early detection and intervention.
Ajuts:	Agencia Estatal de Investigación PSI2017-91814-EXP Agencia Estatal de Investigación PID2020-119211RB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-01010
Nota:	Altres ajuts: The genotyping service was carried out at Centro Nacional de Genotipado (CEGEN-PRB3ISCIII) supported by grant PT17/0019 of the Plan Estatal I+D+i 2013-2016, funded by Instituto de Salud Carlos III (ISCIII) and European Regional Development Fund (ERDF). N.B.V. is supported by the ICREA Academia Award of the Generalitat de Catalunya. P.T. was funded by Ministerio de Ciencia e Innovación (PRE2018085299). P.M.B. was funded by Institut de Biomedicina de la Universitat de Barcelona (IBUB) and the PhD scholarship program FI-SDUR (2021-FISDU-00032) from Agencia de Gestión de Ayudas Universitarias y de Investigación.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Gene-Environment Interaction ; Schizotypy ; Psychosis ; Childhood adversity ; Risk factors ; Resilience ; Psychotic Disorders ; Schizotypal Personality Disorder
Publicat a:	Schizophrenia bulletin, Vol. 51 Núm. Supplement_2 (2025) , p. S95-S106, ISSN 1745-1701

DOI: 10.1093/schbul/sbad130
PMID: 40037819

12 p, 1.5 MB

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