Weight decrease improves live birth rates in obese women undergoing IVF: a pilot study
Espinós, Juan José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública)
Polo, Ana (Fundació Puigvert)
Sánchez-Hernández, Juan (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Bordas, Ramón (Fundació Puigvert)
Pares, Pere (Fundació Puigvert)
Martinez, Olga (Fundació Puigvert)
Calaf Alsina, Joaquim (Fundació Puigvert)

Data:	2017
Resum:	Obese women have lower pregnancy rates than normal-weight women undergoing assisted reproductive treatment. We conducted a pilot study to evaluate whether a 12-week diet and exercise intervention before an IVF cycle would influence pregnancy rates in obese women. Forty-one patients were enrolled in this study. They were randomly allocated to two groups: an intervention group (n = 21), who underwent an individualized diet and physical exercise programme supervised by a dietician, and a control group (n = 20), who started IVF with no previous intervention. The primary outcome was clinical pregnancy rate after a single treatment cycle. Mean weight loss in the study group after the intervention was 5. 4 kg (range 1. 1-14. 6 kg). The study and control groups had similar total FSH consumption, number of oocytes and embryos obtained, and number and quality of embryos transferred. There was a non-significant trend towards a higher clinical pregnancy rate after fresh embryo transfer (66. 7% versus 41. 2%). The intervention group had a significantly higher cumulative live birth rate (61. 9% versus 30%, P = 0. 045) (odds ratio for intervention group, 3. 8; 95% confidence interval, 1. 03 to 13. 9) The data suggest that weight loss resulted in a significantly increased cumulative live birth rate.
Ajuts:	Ministerio de Ciencia e Innovación PI11/02816
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Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	In vitro fertilization ; Obesity ; Diet ; Physical exercise
Publicat a:	Reproductive biomedicine online, Vol. 35, Num. 4 (October 2017) , p. 417-424, ISSN 1472-6491

DOI: 10.1016/j.rbmo.2017.06.019

Postprint 18 p, 607.1 KB

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