Results of a new patch to externally reinforce colorectal anastomosis: an experimental study
Gené Škrabec, Clara (Universitat Autònoma de Barcelona)
Cremades, Manel (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Gatell, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Weis, Christine (B. Braun Surgical S.A.U)
Izco, Jesús M. (Viscofan S.A.)
Rodriguez Rivero, Anna Maria (B. Braun Surgical S.A.U)
Zuñiga, Teresa (Viscofan S.A.)
Parés, David (Universitat Autònoma de Barcelona. Departament de Cirurgia)
Julián Ibáñez, Joan Francesc (Universitat Autònoma de Barcelona. Departament de Cirurgia)

Data:	2025
Resum:	Background: Anastomotic leak (AL) is a serious complication in colorectal surgery, associated with increased morbidity, mortality, and healthcare costs. Technological advances have yet to eliminate AL, which occurs from 5 to 14% of cases involving anastomosis. This study introduces and evaluates a new collagen-cyanoacrylate patch designed to externally reinforce colonic anastomoses with the aim to contain anastomotic leaks. The objective of the study is to evaluate the feasibility and safety of a novel collagen-cyanoacrylate patch to reinforce colonic anastomosis in a porcine model. Materials and Methods: A preclinical study adhering to Good Laboratory Practices (GLP) was conducted on 12 Landrace x Large White pigs. Following a previously validated model for a deficient anastomosis, a 21mm defect was created at a colorectal anastomosis to simulate an AL. Pigs were randomized to receive either reinforcement with the collagencyanoacrylate patch or no reinforcement. Safety and feasibility were assed, analyzing the integration of the patch in colorectal structures. In addition, as a secondary outcomes, we assessed clinical monitoring, behavioral observations, blood tests for inflammatory markers and histopathological analysis. Results: The collagen-cyanoacrylate patch was easily applied, adhered effectively to the bowel surface, successfully sealed the defect, and was naturally degraded during the healing process. No significant differences in stenosis or adhesions were observed between the experimental and control groups, although minor variations in inflammatory and infectious markers were noted. All animals exhibited a 100% survival rate, and no clinical signs of AL were observed. Conclusions: The use of collagen-cyanoacrylate patch is feasible, safe, and has good clinical outcomes, showing promise in preventing colonic AL. Further studies using an adequate anastomotic leak model or clinical studies are needed to confirm efficacy.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Colorectal anastomosis ; Cyanoacrylate ; Collagen patch ; Anastomotic wound healing ; Anastomotic leakage ; Experimental ; Porcine model
Publicat a:	Journal of Surgical Research, Vol. 314 (October 2025) , p. 626-635, ISSN 1095-8673

DOI: 10.1016/j.jss.2025.07.047

10 p, 7.1 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats