Near-infrared activation of upconversion platforms for non-redox-dependent release of Pt(II)
Batten Vera, Marc Ricard (Universitat Autònoma de Barcelona. Departament de Química)
Gutiérrez-Orgaz, Josep A. (Universitat Autònoma de Barcelona. Departament de Química)
Maturi, Fernando Eduardo (Universidade de Aveiro)
Carlos, Luís D. (Universidade de Aveiro)
Oliveira, Helena (Universidade de Aveiro)
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química)
Novio Vázquez, Fernando (Universitat Autònoma de Barcelona. Departament de Química)
Rodríguez-Diéguez, Antonio (Universidad de Granada. Departamento de Química Inorgánica)
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química)
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química)
Bayón Rueda, Joan Pau (Universitat Autònoma de Barcelona. Departament de Química)

Data:	2025
Resum:	Upconversion nanoparticles (UCNPs) are a class of interesting nanomaterials with unique multi-photon excitation photoluminescence properties, and they have been intensively explored as novel contrast agents for biomedical imaging and drug delivery. The development of photoinduced drug-release devices has been intensively developed in the last years, specially using UCNPs due to their properties to absorb single-band near infrared (NIR) light and subsequently emit high-energy UV-to-visible light which could photoactivate several prodrugs. Some examples of Pt(II) release have been described, all of them from Pt(IV) complexes taking advantage of the Pt(IV)/(II) redox couple. In this work, NIR light-responsive LiYF:Yb/Tm UCNPs are presented as carrier systems to exert photoinduced Pt(II) drug release. For this, the surface of UCNPs were coated with an amphiphilic polymer to convert hydrophobic nanoparticles into hydrophilic and to load novel Pt(II) complexes. It is demonstrated that NIR radiation-induced Pt(II) drug release can be achieved without the need to use the Pt(IV)/(II) redox couple as a trigger. In this way, under NIR excitation, UCNPs can transform NIR irradiation into UV radiation which causes direct Pt(II) drug release in a spatial and temporal control manner. The release process has been monitored in real-time. Two platforms containing two different Pt(II) complexes have been studied, both showing similar results in terms of the enhancement of toxicity caused by the increase in Pt(II) concentration. Furthermore, a significant improvement of cytotoxicity against melanoma A375 cells was observed after irradiation of these platforms, confirming the feasibility of the proposed upconversion process to release Pt(II).
Ajuts:	Agencia Estatal de Investigación PID2022-138479NB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00668 Agencia Estatal de Investigación PID2021-127983OB-C21
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Upconversion ; Nanoparticles ; Platinum ; Release ; Cancer ; Photoactivation
Publicat a:	Journal of inorganic biochemistry, Vol. 271 (October 2025) , art. 112982, ISSN 1873-3344

DOI: 10.1016/j.jinorgbio.2025.112982

17 p, 5.8 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats