Ayahuasca-assisted meaning reconstruction therapy as an early resource for bereavement: a non-randomized clinical trial
Soto-Angona, Óscar (Universitat Autònoma de Barcelona)
Andión Pérez, Óscar (Research Sherpas, Girona)
Sabucedo, Pablo (University of Liverpool)
Neimeyer, Robert A (Portland Institute for Loss and Transition, Portland)
Haro Abad, Josep Maria (Institut de Recerca Sant Joan de Déu)
Javkin, Julia (Sociedad Española de Medicina Psicodélica)
Farré Albaladejo, Magí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
González, Débora (Institut de Recerca Sant Joan de Déu)

Data:	2025
Resum:	Preliminary evidence suggests that ayahuasca may alleviate severe grief symptoms. This three-arm, sequentially allocated, open-label study examines the therapeutic changes associated with ayahuasca-assisted meaning reconstruction therapy (A-MR) compared to meaning reconstruction therapy alone (MR) and a no-treatment control (NT). A total of 84 adults experiencing severe grief within 12 months of losing a first-degree relative were allocated to A-MR (n = 28), MR (n = 28), or NT (n = 28). Grief severity, prolonged grief disorder symptoms, post-traumatic growth, and quality of life were assessed at baseline, after the intervention, and 3 months post-intervention. Ayahuasca was well tolerated, with no serious adverse events reported. All groups showed significant grief severity reduction (A-MR: p < . 0001, d = 2. 44; MR: p < . 0001, d = 1. 84; NT: p < . 002, d = 0. 74). Greater reductions were observed in the A-MR compared to MR (p = . 012, d = 0. 86) and NT (p = . 0008, d = 1. 07). A-MR was also associated with significant improvements in prolonged grief symptomatology, post-traumatic growth, and quality of life, with medium-to-large effect sizes. This is the first controlled prospective study to provide preliminary support for A-MR as a safe and potentially effective intervention for severe grief, though replication in larger randomized trials is required.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Ayahuasca ; Bereavement ; Clinical trial ; Grief ; Meaning reconstruction ; Prolonged grief disorder ; Psychedelic-assisted therapy
Publicat a:	Scientific reports, Vol. 15 Núm. 1 (September 2025) , ISSN 2045-2322

DOI: 10.1038/s41598-025-13251-5
PMID: 40890317

14 p, 2.4 MB

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