Gene therapy as a treatment for type 2 Diabetes (T2D) and Obesity
Hussain Kousar, Muhammad Umer
Jimenez, Veronica, tut. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Universitat Autònoma de Barcelona. Facultat de Biociències

Date:	2025
Abstract:	Type 2 Diabetes and Obesity are closely related metabolic disorders that have risen to epidemic levels causing major health concern. T2D, comprising 95% of diabetes cases, is characterized by insulin resistance and persistent hyperglycemia. Notably, two-thirds of T2D patients are overweight. Obesity, defined by excessive adipose tissue accumulation due to energy imbalance, triggers chronic inflammation contributing to insulin resistance and metabolic dysfunctions. Given their close connection, clinical studies emphasize the importance of integrated strategies to achieve more effective management of both T2D and Obesity. The heritability of these conditions ranges from 45% to 90%, with over 75 loci linked to T2D, highlighting a strong genetic foundation. Gene Therapy aims to cure the disease by modifying the patient's genes. Through inactivation, replacement or mutation-editing, it targets the underlying genetic causes, unlike conventional treatments that focus on symptom management. Therefore, it offers the potential for long-lasting, effective interventions, making it a potentially transformative strategy for treating T2D and Obesity.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra, i la creació d'obres derivades, sempre que no sigui amb finalitats comercials i que es distribueixin sota la mateixa llicència que regula l'obra original. Cal que es reconegui l'autoria de l'obra original.
Language:	Anglès
Studies:	Bioquímica [2500252]
Study plan:	Grau en Bioquímica [814]
Document:	Treball final de grau

1 p, 3.4 MB

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Research literature > Bachelor's degree final project > Biosciences Faculty