Challenge of long-term benzodiazepine use in primary care : insights from a real-world cohort study in Catalonia
Peñarrubia-Maria, Maria Teresa (Universitat de Barcelona)
Parker, Lucy Anne (Universidad Miguel Hernández (Elx, Alacant))
Puig-García, Marta (Universidad Miguel Hernández (Elx, Alacant))
Fuente-Moreno, Marina (Institut de Recerca Pediàtrica Hospital San Joan de Déu de Barcelona)
Lumbreras Lacarra, Blanca (Universidad Miguel Hernández de Elche)
Lopez-Pintor, Elsa (Universidad Miguel Hernández (Elx, Alacant))
Domènech-Abella, Joan (Institut de Recerca Pediàtrica Hospital San Joan de Déu de Barcelona)
Saez, Marc (Universitat de Girona)
Dima, Alexandra Lelia (Universitat Autònoma de Barcelona. Institut Universitari Avedis Donabedian)
Figueiras Guzmán, Adolfo (Universidade de Santiago de Compostela)
Chilet Rosell, Elisa (Universidad Miguel Hernández (Elx, Alacant))
Serrano-Blanco, Antoni (Parc Sanitari Sant Joan de Déu)
Aznar-Lou, Ignacio (Institut de Recerca Pediàtrica Hospital San Joan de Déu de Barcelona)

Data:	2025
Resum:	Long-term use of benzodiazepines (BZD) triggers health problems. Although Spain leads European use of BZD, the number of long-term users (LTUs) remains unknown. The aim of the study is to estimate the proportion of primary care (PC) patients who initiate a BDZ prescription that subsequently become LTU and to identify its associated factors. Retrospective real-world data cohort. It included the population over 15 years with a new prescription of BZD in PC in Catalonia. Users were considered LTU if they had been dispensed at least three prescriptions within 3 months. Sociodemographic characteristics of patients and prescribers, pathologies, previous BZD use, number and type of visits, and prescription quality standard were considered. We estimated the proportion of LTU among patients with a new prescription, stratified by age and sex, and estimated risk factors by multivariate generalised linear models. 100 638 users with a new BZD prescription were included. 27. 1% were LTU at 3 months and 14. 5% at 6 months. LTU increases with age and is higher in women. Predictors of LTU are Spanish nationality, living in rural areas, having a mental illness, having used BZD, having virtual visits or not meeting pharmacy-therapeutic quality standards. The number of patients who develop LTU is high, especially in the elderly. Exploring the causes of this phenomenon could contribute to the development of future interventions.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Public Health ; Epidemiology ; Pharmacology ; Primary Health Care ; Mental Health
Publicat a:	Family Medicine and Community Health, Vol. 13 (july 2025) , ISSN 2009-8774

DOI: 10.1136/fmch-2024-003233
PMID: 40744657

10 p, 834.9 KB

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