Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers
Fagundo, Ana Beatriz (Hospital Universitari de Bellvitge)
Fernández Aranda, Fernando (Hospital Universitari de Bellvitge)
De La Torre, Rafael (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Verdejo-Garcia, Antonio (Monash University (Melbourne, Austràlia))
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Penelo Werner, Eva (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut)
Gené Badia, Manel (Universitat de Barcelona)
Barrot, Carme (Universitat de Barcelona)
Sánchez, Cristina (Universitat de Barcelona)
Alvarez-Moya, Eva M. (Hospital Universitari de Bellvitge)
Ochoa, Cristian (Universitat de Barcelona)
Aymamí, Neus (Hospital Universitari de Bellvitge)
Gomez-Peña, Monica (Hospital Universitari de Bellvitge)
Menchón Magriñá, José Manuel (Hospital Universitari de Bellvitge)
Jiménez-Murcia, Susana (Hospital Universitari de Bellvitge)

Date:	2014
Description:	13 pàg.
Abstract:	Like drug addiction, pathological gambling (PG) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (DA) in the executive profile of PG remains unclear. The aim of this study was to identify whether the DRD2/ANKK1 Taq1Ars1800497 and the DAT1-40 bp VNTR polymorphisms are associated with cognitive flexibility (measured by Wisconsin Card Sorting Test (WCST) and Trail Making Test (TMT)) and inhibition response (measured by Stroop Color and Word Test (SCWT)), in a clinical sample of 69 PG patients. Our results showed an association between DA functioning and cognitive flexibility performance. The Taq1A A1+ (A1A2/A1A1) genotype was associated with poorer TMT performance (p < 0. 05), while DAT1 9-repeat homozygotes displayed better WCST performance (p < 0. 05) than either 10-repeat homozygotes or heterozygotes. We did not find any association between the DRD2 or DAT1 polymorphisms and the inhibition response. These results suggested that pathological gamblers with genetic predispositions toward lower availability of DA and D2 receptor density are at a higher risk of cognitive flexibility difficulties. Future studies should aim to shed more light on the genetic mechanisms underlying the executive profile in PG.
Grants:	Ministerio de Ciencia e Innovación PSI2011-28349 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014/SGR-1672 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009/SGR-718 Ministerio de Ciencia e Innovación JCI-2011-09248
Note:	Altres ajuts: This work was supported by the Fondo de Investigación Sanitaria (FIS) [foundation for health investigation] (grant number PI11/210)
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Addiction ; Cognition ; Cognitive flexibility ; Dopamine ; Dopamine receptor ; Dopamine transport ; Executive functions ; Gambling ; Genetics ; Inhibition response ; Pathological gambling ; Polymorphism
Published in:	Journal of Psychopharmacology, Vol. 28, Núm. 12 (2014) , p. 1170-1177, ISSN 1461-7285

DOI: 10.1177/0269881114551079

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