Evaluating the efficacy of radically open dialectical behavior therapy (RO-DBT) in patients with anorexia nervosa : study protocol for a randomized controlled clinical trial
Avila-Parcet, Aina (Institut de Recerca Sant Pau)
Martin Blanco, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Gawron, Leonor (Institut de Recerca Sant Pau)
Cano, Marta (Institut de Recerca Sant Pau)
De la Peña-Arteaga, Víctor (Institut de Recerca Sant Pau)
Carceller-Sindreu, Mar (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Soler, Joaquim (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Portella Moll, Maria J., 1975- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Faustino, Gloria (Institut de Recerca Sant Pau)
Cardoner, N. (Narcís) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Carmona i Farrés, Cristina (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)

Date:	2025
Abstract:	Anorexia nervosa (AN) is a severe and disabling disorder, with relapse rates as high as 50% after the first episode, posing a significant challenge for clinicians. Most therapies excessively focus on nourishment, resulting in temporary weight restoration but with no improvements in general well-being and quality of life. Radically Open Dialectical Behavior Therapy (RO-DBT) is a transdiagnostic treatment designed to address overcontrol, a key aspect in the functioning of patients with AN. To date, no clinical trial (CT) has shown its efficacy in these patients or evaluated its neurobiological mechanism of action. A randomized CT in weight restored adult AN patients will be conducted, with one group receiving treatment as usual (TAU) and the other TAU plus RO-DBT, with the main outcome being quality of life. Secondary variables will include eating disorders (EDs) symptoms, overcontrol characteristics, autistic traits, and neuroimaging changes. The results will address a gap in knowledge regarding AN treatment, with the expectation that patients receiving TAU with RO-DBT will exhibit improved quality of life and experience fewer relapses at the one-year follow-up. This is the first study examining neuroimaging changes in RO-DBT to better understand its underlying mechanisms.
Grants:	Instituto de Salud Carlos III CD20/00189 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00832
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Anorexia nervosa ; Radically open dialectical behaviour therapy ; Neuroimaging ; Overcontrol ; Efficacy
Published in:	BMC Psychiatry, Vol. 25 Núm. 1 (April 2025) , ISSN 1471-244X

DOI: 10.1186/s12888-025-06854-9
PMID: 40251556

11 p, 1.5 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles