Frailty assessment in adults undergoing allogeneic hematopoietic cell transplantation : insights from a multicenter GETH-TC study to optimize outcomes and care
Salas, María Queralt (Hospital Clínic i Provincial de Barcelona)
Solano, María Teresa (Hospital Clínic i Provincial de Barcelona)
Baile González, Mónica (Complejo Asistencial Universitario de Salamanca/IBSAL)
Acera Gómez, Marina (Complejo Asistencial Universitario de Salamanca/IBSAL)
Fox, Laura (Hospital Universitari Vall d'Hebron)
Pérez Artigas, María del Mar (Hospital Universitari Vall d'Hebron)
Santamaría, Ana (Hospital Álvaro Cunqueiro (Vigo))
Quintela González, María del Carmen (Hospital Álvaro Cunqueiro (Vigo))
Sánchez Salinas, Andrés (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Salmerón Camacho, Joaquina M. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Illana Álvaro, Verónica (Hospital Universitario de la Princesa (Madrid))
Abdallahi-Lefdil, Zahra (Hospital Universitario de la Princesa (Madrid))
Cornago Navascues, Javier (Hospital Universitario Fundación Jiménez Díaz)
Pardo, Laura (Hospital Universitario Fundación Jiménez Díaz)
Fernández-Luis, Sara
Vega Suárez, Leddy Patricia (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Villar, Sara (Clínica Universidad de Navarra)
Beorlegui-Murillo, Patricia (Clínica Universidad de Navarra)
Esquirol, Albert (Institut de Recerca Sant Pau)
Izquierdo García, Isabel (Hospital Universitario Miguel Servet (Saragossa))
Rodríguez González, Sonia (Universitat de Barcelona)
Mussetti, Alberto (Universitat de Barcelona)
Lavilla, Esperanza (Hospital Universitario Lucus Augusti (Lugo))
Lopez-Marín, Javier (Hospital General Universitario de Alicante (Alacant, País Valencià))
Filaferro, Silvia (Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular)
Cedillo Cedillo, Angel (Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular)
Bento, Leyre (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Sureda, Anna (Grupo Español de Trasplante de Progenitores Hematopoyéticos y Terapia Celular)

Data:	2025
Resum:	This multicenter prospective study sponsored by the Grupo Español de Transplante Hematopoyético y Terapia Celular (GETH-TC) explores the use of frailty assessments in allo-HCT candidates. Frailty was measured using the HCT Frailty Scale at first consultation and HCT admission in 404 adults from 15 HCT programs in Spain. Based on the results, patients were classified into fit, pre-frail and frail categories. Allo-HCT outcomes were analyzed according to the results obtained from the HCT Frailty Scale. Data was collected prospectively and all patients signed informed consent. At first consultation, 102 (26. 2%) patients were classified as fit, 248 (61. 4%) as pre-frail, and 50 (12. 4%) as frail. During the study, 62 (15. 2%) patients participated in a pre-habilitation program. Among non-pre-habilitated patients (n=342), the proportion of fit patients decreased from 26. 6% to 16. 7%, while frail patients increased from 12. 7% to 19. 9%. In contrast, pre-habilitated patients (n=62) showed improvements, with fit patients increasing from 24. 2% to 46. 8%, and frail patients decreasing from 9. 7% to 3. 2%. Multivariate analysis confirmed lower OS (HR 2. 52, P=0. 002) and higher NRM (HR 2. 69, P=0. 013) in frail patients at HCT admission compared to fit ones, with a trend towards lower OS in pre-frail patients (HR 1. 54, P=0. 097). This study highlights the feasibility of incorporating the HCT Frailty Scale into clinical practice, confirms its negative impact of frailty on transplant outcomes, and suggests that frailty is dynamic and potentially reversible through pre-transplant interventions.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Frailty syndrome ; HCT Frailty Scale ; allogeneic-HCT ; Pre-habilitation ; Survival
Publicat a:	Frontiers in immunology, Vol. 15 (January 2025) , ISSN 1664-3224

DOI: 10.3389/fimmu.2024.1512154
PMID: 39840039

14 p, 3.8 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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