Progressive Encephalomyelitis With Rigidity and Myoclonus With Glycine Receptor Antibodies
Guasp, Mar (Hospital Clínic i Provincial de Barcelona)
Saiz, Albert (Hospital Clínic i Provincial de Barcelona)
Ruiz-Vives, Marina (Hospital Clínic i Provincial de Barcelona)
Almendrote, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bruna, Jordi (Hospital Universitari de Bellvitge)
González-Menacho, Jordi (Hospital Universitari Joan XXIII de Tarragona. Institut d'Investigació Sanitària Pere Virgili)
Kaneko, Juntaro (Kitasato University School of Medicine)
Martín-Aguilar, Lorena (Institut de Recerca Sant Pau)
Martínez-García, Francisco Antonio (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Noda, Kazuyuki (Juntendo University Shizuoka Hospital)
Ruiz Molina, Angel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Sequeiros, Sara (Hospital Álvaro Cunqueiro (Vigo))
Simabukuro, Mateus Mistieri (Hospital de Clínicas de Porto Alegre (Brasil))
Takenaka, Megumi (Chugoku Rosai Hospital)
Zurdo, Martín (Hospital Virgen del Puerto)
Dalmau, Josep (Hospital Clínic i Provincial de Barcelona)
Iizuka, Takahiro (Kitasato University School of Medicine)
Graus Ribas, Francesc (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Date:	2025
Abstract:	The aim of this study was to describe the clinical features and long-term outcome of patients with glycine receptor (GlyR) antibody-mediated progressive encephalomyelitis with rigidity and myoclonus (PERM), a disease commonly included under the term of stiff-person spectrum disorders (SPSDs). We conducted a retrospective analysis of patients with PERM and GlyR antibodies diagnosed in our laboratory and a systematic literature review (following Preferred Reporting Items for Systematic Reviews and Meta-Analyses [PRISMA] 2020 reporting guideline) of previously reported patients with sufficient clinical information and ≥12 months of follow-up. Neurologic disability was measured with the modified Rankin Scale (mRS). Relapses were defined as any event occurring.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Neurology® neuroimmunology & neuroinflammation, Vol. 12 Núm. 6 (September 2025) , ISSN 2332-7812

DOI: 10.1212/NXI.0000000000200473
PMID: 40953327

11 p, 1.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles