Experience dependent plasticity of higher visual cortical areas in the mouse
Craddock, Rosie (School of Biosciences, Cardiff (Regne Unit))
Vasalauskaite, Asta (School of Biosciences (Cardiff, Regne Unit))
Ranson, Adam (Universitat Autònoma de Barcelona. Institut de Neurociències)
Sengpiel, Frank (Cardiff University)

Date:	2023
Abstract:	Experience dependent plasticity in the visual cortex is a key paradigm for the study of mechanisms underpinning learning and memory. Despite this, studies involving manipulating visual experience have largely been limited to the primary visual cortex, V1, across various species. Here we investigated the effects of monocular deprivation (MD) on the ocular dominance (OD) and orientation selectivity of neurons in four visual cortical areas in the mouse: the binocular zone of V1 (V1b), the putative "ventral stream" area LM and the putative "dorsal stream" areas AL and PM. We employed two-photon calcium imaging to record neuronal responses in young adult mice before MD, immediately after MD, and following binocular recovery. OD shifts following MD were greatest in LM and smallest in AL and PM; in LM and AL, these shifts were mediated primarily through a reduction of deprived-eye responses, in V1b and LM through an increase in response through the non-deprived eye. The OD index recovered to pre-MD levels within 2 weeks in V1 only. MD caused a reduction in orientation selectivity of deprived-eye responses in V1b and LM only. Our results suggest that changes in OD in higher visual areas are not uniformly inherited from V1.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ocular dominance ; Orientation selectivity ; Two-photon calcium imaging ; Visual cortex
Published in:	Cerebral cortex (New York, N.Y.), Vol. 33 (june 2023) , p. 9303-9312, ISSN 1460-2199

DOI: 10.1093/cercor/bhad203
PMID: 37279562

10 p, 1.3 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
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Articles > Published articles