Streptococcus suis infection on European farms is associated with an altered tonsil microbiome and resistome
Fredriksen, Simen (Wageningen University)
Neila-Ibáñez, Carlos María (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Hennig-Pauka, Isabel (University of Veterinary Medicine Hannover)
Guan, Xiaonan (Schothorst Feed Research B.V)
Dunkelberger, Jenelle (Topigs Norsvin USA)
de Oliveira, Isabela Fernandes (Wageningen University)
Ferrando, Maria Laura (Wageningen University)
Correa-Fiz, Florencia (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Aragón, Virginia (Universitat Autònoma de Barcelona. Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal)
Boekhorst, Jos (Wageningen University)
van Baarlen, Peter (Wageningen University)
Wells, Jerry M. (Wageningen University)

Date:	2024
Abstract:	Streptococcus suis is a Gram-positive opportunistic pathogen causing systemic disease in piglets around weaning age. The factors predisposing to disease are not known. We hypothesized that the tonsillar microbiota might influence disease risk via colonization resistance and/or co-infections. We conducted a cross-sectional case-control study within outbreak farms complemented by selective longitudinal sampling and comparison with control farms without disease occurrence. We found a small but significant difference in tonsil microbiota composition between case and control piglets (n =45+45). Variants of putative commensal taxa, including Rothia nasimurium, were reduced in abundance in case piglets compared to asymptomatic controls. Case piglets had higher relative abundances of Fusobacterium gastrosuis, Bacteroides heparinolyticus and uncultured Prevotella and Alloprevotella species. Piglets developing disease post-weaning had reduced alpha diversity pre-weaning. Despite case-control pairs receiving equal antimicrobial treatment, case piglets had a higher abundance of antimicrobial resistance genes conferring resistance to antimicrobial classes used to treat S. suis. This might be an adaption of disease-associated strains to frequent antimicrobial treatment.
Grants:	European Commission 727966
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	AMR ; Colonization resistance ; S. suis carriage ; S. suis infection ; Streptococcus suis ; Tonsil microbiome
Published in:	Microbial Genomics, Vol. 10 (december 2024) , ISSN 2057-5858

DOI: 10.1099/mgen.0.001334
PMID: 39699589

14 p, 546.7 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Centre de Recerca en Sanitat Animal (CReSA-IRTA)
Articles > Research articles
Articles > Published articles