Age-related differences in cardiogenic shock secondary to Takotsubo syndrome
Tomasino, Marco (Vall d'Hebron Institut de Recerca (VHIR))
Vazirani Ballesteros, Ravi (Hospital Clínico San Carlos (Madrid))
Salamanca, Jorge (Hospital Universitario de La Princesa (Madrid))
Raposeiras-Roubin, Sergio (Hospital Álvaro Cunqueiro (Vigo))
Fernández-Cordon, Clara (Hospital Clínico Universitario (Valladolid))
Corbí-Pascual, Miguel (Complejo Hospitalario Universitario de Albacete)
Vedia Cruz, Oscar (Hospital Universitario de Torrejón)
Martin-Garcia, Agustin C. (Complejo Asistencial Universitario de Salamanca)
Blanco, Emilia (Hospital Arnau de Vilanova (Lleida, Catalunya))
Almendro-Delia, Manuel (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Piserra López, Alberto (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Larre Guerra, Jaime Francisco (Hospital Universitario Fundación Jiménez Díaz)
Gonzalez-Santorum, Francisco (Vall d'Hebron Institut de Recerca (VHIR))
Lluch Requerey, Carmen (Hospital Universitario Juan Ramón Jiménez)
Guillén Marzo, Marta (Hospital Universitari Joan XXIII de Tarragona)
Pérez-Castellanos, Alberto (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Ridocci-Soriano, Francisco (Hospital General Universitario de Valencia)
López-Pais, Javier (Hospital Universitario de Santiago)
Andrea-Riba, Rut (Hospital Clínic i Provincial de Barcelona)
Sionis, Alessandro (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Nuñez-Gil, Ivan Javier (Universidad Europea de Madrid)
Uribarri, Aitor (Universitat Autònoma de Barcelona. Departament de Medicina)
Universitat Autònoma de Barcelona. Departament de Medicina

Date:	2025
Abstract:	Background: Age-related differences in Takotsubo Syndrome (TTS) have been described, but there is limited information regarding TTS patients who develop cardiogenic shock (CS). Methods and Results: We analysed data from 408 CS-TTS patients in the RETAKO registry. Patients were stratified into three age groups: ≤50 years (9%), 51-74 years (48%), and ≥75 years (43%). In the youngest group, compared to the middle-aged and the oldest groups, patients were more likely to be male (35% vs. 16% and 14%, p =. 01), have a physical trigger (65% vs. 43% and 49%, p =. 04), exhibit atypical echocardiographic patterns (27% vs. 11% and 11%, p =. 02), and experienced a higher incidence of ventricular arrhythmias (24% vs. 8% and 7%, p =. 01). In-hospital mortality rates were 5% in younger patients, 12% in middle-aged patients, and 15% in older patients (p =. 15). Older age independently predicted both in-hospital mortality (OR 2. 33, 95% CI 1. 05-5. 17; reference: middle-aged) and 5-year mortality (HR 3. 69, 95% CI 1. 77-7. 67), regardless of shock severity. Conclusions: In CS-TTS, younger patients exhibit distinct clinical features but have better outcomes. Older age is associated with higher in-hospital and long-term mortality, regardless of comorbidities and shock severity. These findings underscore the need for age-specific management strategies and further research into the mechanisms underlying age-related differences in CS-TTS.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Age- related differences ; Cardiogenic shock ; Heart failure ; Left ventricular dysfunction ; Stresscardiomyopathy ; Takotsubo
Published in:	European Journal of Clinical Investigation, Vol. 56, Num. 1 (January 2025) , art. e70119, ISSN 1365-2362

DOI: 10.1111/eci.70119

12 p, 806.0 KB

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