Management of women with endometriosis in the 21st century
Di Spiezio Sardo, Attilio (University of Naples Federico II)
Becker, Christian M. (University of Oxford (Regne Unit))
Renner, Stefan P. (Hospital Böblingen)
Suvitie, Pia A. (University of Turku)
Estadella Tarriel, Josep (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Vannuccini, Silvia (Careggi University Hospital (Florència, Itàlia))
Garcia Velasco, Juan A (Universitat Rey Juan Carlos (Madrid))
Verguts, Jasper (Hasselt University)
Mercorio, Antonio (University Versailles)

Data:	2025
Resum:	Endometriosis is a chronic inflammatory condition that significantly affects women's quality of life and fertility. Despite advancements in treatment, many areas of uncertainty persist in clinical management. This review provides a symptom-focused, patient-centered update, addressing cases from asymptomatic to those complicated by pain and infertility Advancement in imaging technology has increased incidental diagnoses of asymptomatic endometriosis, raising the debate between immediate treatment and watchful waiting. Medical therapy primarily aims to suppress symptoms, with oral gonadotropin-releasing hormone antagonists and add-back therapy offering promising long-term pain control. Research into local neurogenesis and central sensitization supports complementary approaches, though high-quality evidence is still limited. For pain refractory to medical therapy, conservative surgical strategies can minimize postoperative complications without significantly increasing recurrence rates. In infertility, assisted reproductive technology (ART) provides effective options, although the optimal endometrial preparation and the necessity of pre-ART surgery remain to be fully elucidated The optimal management of endometriosis requires a personalized, multidisciplinary approach within specialized centers. Long-term suppressive medical therapy remains the cornerstone of pain management while emerging targeted agents hold promise for better symptom control with fewer side effects. Surgical intervention should be performed by experienced surgeons as a single definitive procedure when possible. Tailored ART protocols can address infertility challenges. Standardized classification systems and robust randomized trials are crucial to refining treatment pathways, optimizing fertility outcomes, and enhancing quality of life.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Endometriosis ; Infertility ; Minimally invasive surgery ; Pelvic pain
Publicat a:	Current opinion in obstetrics and gynecology, Vol. 37 Núm.3 (June 2025) , p. 149-157, ISSN 1473-656X

DOI: 10.1097/GCO.0000000000001027
PMID: 40237624

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