Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease

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Comparison of the amyloid plaque proteome in Down syndrome, early-onset Alzheimer's disease, and late-onset Alzheimer's disease
Martá-Ariza, M. (Universitat Autònoma de Barcelona. Institut de Neurociències)
Leitner, D.F. (NYU Langone Health and Grossman School of Medicine)
Kanshin, E. (NYU Grossman School of Medicine)
Suazo, J. (NYU Grossman School of Medicine)
Giusti Pedrosa, A. (New York University)
Thierry, M. (NYU Grossman School of Medicine)
Lee, E.B. (Perelman School of Medicine at the University of Pennsylvania)
Devinsky, O. (NYU Langone Health and Grossman School of Medicine)
Drummond, E. (University of Sydney)
Fortea, Juan

(Institut de Recerca Sant Pau)
Lleó, Alberto

(Institut de Recerca Sant Pau)
Ueberheide, B. (NYU Grossman School of Medicine)
Wisniewski, Thomas M. (NYU Grossman School of Medicine)

Fecha:	2025
Resumen:	Down syndrome (DS) is strongly associated with Alzheimer's disease (AD) due to APP overexpression, exhibiting Amyloid-β (Aβ) and Tau pathology similar to early-onset (EOAD) and late-onset AD (LOAD). We evaluated the Aβ plaque proteome of DS, EOAD, and LOAD using unbiased localized proteomics on post-mortem paraffin-embedded tissues from four cohorts (n = 20/group): DS (59. 8 ± 4. 99 y/o), EOAD (63 ± 4. 07 y/o), LOAD (82. 1 ± 6. 37 y/o), and controls (66. 4 ± 13. 04). We identified differentially abundant proteins when comparing Aβ plaques and neighboring non-plaque tissue (FDR < 5%, fold-change.
Ayudas:	Instituto de Salud Carlos III PI20/01473 Instituto de Salud Carlos III PI23/01786
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Alzheimer's disease ; Amyloid-β ; Down syndrome ; Neuropathology ; Proteomics
Publicado en:	Acta Neuropathologica, Vol. 149 Núm. 1 (june 2025) , p. 9, ISSN 1432-0533

30 p, 8.1 MB

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