Catatonia in first-episode psychosis : prevalence and psychopathological association
Cuevas-Esteban, Jorge (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Serrat, Francesc (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Iglesias-González, Maria (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Motta, Nicole (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Jimenez-Fernandez, Beltran (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vila-Badia, Regina (Institut de Recerca Sant Joan de Déu)
Colomer-Salvans, Alicia (Institut de Recerca Sant Joan de Déu)
Serra-Arumí, Clara (Institut de Recerca Sant Joan de Déu)
Del Cacho, Núria (Institut de Recerca Sant Joan de Déu)
Corbella-Sotil, Ariadna (Institut de Recerca Sant Joan de Déu)
Butjosa, Anna (Institut de Recerca Sant Joan de Déu)
Pardo, Marta (Institut de Recerca Sant Joan de Déu)
Usall, Judith (Institut de Recerca Sant Joan de Déu)

Data:	2025
Resum:	Background First-episode psychosis (FEP) is a critical phase in psychotic disorders where early intervention significantly influences long-term outcomes. Catatonia, characterised by motor, behavioural, and psychological abnormalities, is an under-recognised aspect of FEP. Aims This study examines catatonia prevalence in affective and non-affective FEP, its role as a severity indicator across psychopathological domains, its correlations with other symptoms and its association with clinical syndromes. Method A cross-sectional study was conducted with 58 FEP patients (38 females, 20 males) aged 15-55 years. Of those, 40 were antipsychotic-naive, and 18 had minimal prior antipsychotic exposure. Participants were recruited from acute psychiatric units. Catatonia was assessed using the Bush Francis Catatonia Rating Scale (BFCRS), while psychopathology was evaluated with the Positive and Negative Symptom Scale (PANSS), Calgary Depression Scale (CDS) and Young Mania Rating Scale (YMRS). Data analysis included descriptive statistics, t-tests, χ tests, and multivariable regression using SPSS version 25 for Windows. Results Catatonic signs were identified in 22. 4% of cases based on the Bush Francis Catatonia Screening Instrument (BFCSI) criteria (BFCSI-positive group, defined as ≥2 signs present for over 24 h), indicating potential catatonia. Prevalence varied by criteria: 13. 8% (DSM-IV), 10. 3% (Fink and Taylor), 10. 38% (ICD-11) and 8. 6% (DSM-5). Catatonic patients had more years of education and significantly higher PANSS totals, Emsley negative, disorganised, excited, and anxiety scores. Catatonic signs moderately correlated with Emsley disorganised scores. Regression analysis identified PANSS total and Emsley domain scores as significant predictors of catatonia severity. Conclusions Catatonia is notably prevalent in FEP and associated with severe psychopathology, particularly in negative and disorganised domains. These findings underscore the importance of improving recognition of catatonia in early psychosis. Larger longitudinal studies are needed to confirm these findings and explore treatment implications.
Ajuts:	Instituto de Salud Carlos III PI17/00111
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	First-episode psychosis ; Catatonia ; Prevalence ; Affective psychosis ; Non-affective psychosis
Publicat a:	BJPsych Open, Vol. 11, Num. 5 (September 2025) , art. e220, ISSN 2056-4724

DOI: 10.1192/bjo.2025.10834
PMID: 40985102

7 p, 264.8 KB

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