Spanish Multicenter Megaprosthesis Study (MEGAPROT) on 816 Tumor Prostheses : Main Results
Pérez Muñoz, I. (Hospital Universitario Ramón y Cajal (Madrid))
González Lizán, F. (Hospital Universitario Ramón y Cajal (Madrid))
Sanz Pascual, M.d.C. (Hospital Universitario Ramón y Cajal (Madrid))
Machado Granados, Pau (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Peiró, Ana (Institut de Recerca Sant Pau)
Angulo Sánchez, M. (Hospital Universitari i Politècnic La Fe (València))
de la Calva Ceinos, C. (Hospital Universitari i Politècnic La Fe (València))
González Rojo, Paula (Hospital Universitari i Politècnic La Fe (València))
Asua Mentxaka, L. (Hospital Universitario de Cruces (Barakaldo, País Basc))
Arteagoitia, I. (Hospital Universitario de Cruces (Barakaldo, País Basc))
Hernández González, N. (Hospital Universitario de Cruces (Barakaldo, País Basc))
Merino Pérez, J. (Hospital Universitario de Cruces (Barakaldo, País Basc))
Zarzuela, V.M. (Hospital General Universitario de Valencia)
Puertas García-Sandoval, P. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Valero Cifuentes, G. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Valcárcel Díaz, A. (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Godoy Montijano, A. (Hospital Universitario Virgen de las Nieves (Granada))
Fernández Serrano, F. (Hospital Universitario Virgen de las Nieves (Granada))
González Acha, J. (Hospital de Donostia (Sant Sebastià, País Basc))
Esnaloa, P. (Hospital de Donostia (Sant Sebastià, País Basc))
Chaves Dorta, I. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Coll Mesa, L. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Baz Figueroa, C. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Álvarez Garma, Á. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Orce, A. (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Cebrián Parra, J.L. (Hospital Clínico San Carlos (Madrid))
García Maroto, R. (Hospital Clínico San Carlos (Madrid))
Pablos Gonzalez, Oscar (Hospital Universitari de Bellvitge)
Maireles Pérez, Miriam (Hospital Universitari de Bellvitge)
Fontalva Guerrero, María Luisa (Hospital Universitari de Bellvitge)
Garcés Zarzalejo, C. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Estellés Marcos de León, L.R. (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Gracia, Isidro (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2025
Abstract:	(1) Background: The use of tumor megaprostheses faces challenges, but the published series are typically small and offer limited solutions. Our aim was to compile a large series; describe patient profiles and surgical techniques; analyze prosthetic survival identifying factors affecting survival; and provide a basis for future subanalyses. (2) Methods: This is a retrospective observational multicenter study that included patients with a tumor megaprosthesis in any anatomical location. Demographic, etiologic, and surgical variables were analyzed. Data on complications and survival were also collected. (3) Results: Our series includes a total of 816 prostheses (585 primary, 181 revision, and 50 second revision). The patients' mean age was 44. 2 ± 20. 8 years. Primary surgeries were performed on the femur (n = 404; 69. 1%), tibia (n = 79; 13. 5%), humerus (n = 74; 12. 6%), pelvis (n = 20; 3. 4%), and scapula (n = 4; 0. 7%). Survival following primary surgery was 73. 3% at 10 years. No statistically significant differences were found with respect to survival from primary surgery between males and females (p = 0. 194), between the different etiologies (p = 0. 540), or between the lower and the upper limb (p = 0. 618). In contrast, statistically significant survival differences were found when the type of fixation was analyzed (p < 0. 001). (4) Conclusions: This study analyzed one of the largest series of patients treated with tumor megaprostheses, demonstrating their acceptable survival and validating them as a treatment option for bone tumors.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Megaprostheses ; Tumor ; Prostheses ; Survival ; Orthopedics ; Fixation ; Coating ; Neoplasm ; Osteosarcoma
Published in:	Prosthesis, Vol. 7 Núm. 1 (february 2025) , p. 2, ISSN 2673-1592

DOI: 10.3390/prosthesis7010002

13 p, 734.9 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles