Centenarians-the way to healthy vascular ageing and longevity : a review from VascAgeNet
Summer, S. (University for Continuing Education Krems)
Borrell-Pages, Maria (Institut de Recerca Sant Pau)
Bruno, R.M. (Hôpital Européen Georges Pompidou (París, França))
Climie, R.E. (University of Tasmania)
Dipla, K. (Aristotle University of Thessaloniki)
Dogan, A. (Yeditepe University)
Eruslanova, K. (Pirogov Russian National Research Medical University)
Fraenkel, E. (University of Košice)
Mattace-Raso, F. (Erasmus University Rotterdam)
Pugh, C.J.A. (Cardiff Metropolitan University)
Rochfort, K.D. (Dublin City University)
Ross, M. (Heriot-Watt University)
Roth, L. (University of Antwerp)
Schmidt-Trucksäss, A. (University of Basel)
Schwarz, D. (University of Münster)
Shadiow, J. (University of Michigan)
Sohrabi, Y. (Charles University)
Sonnenberg, J. (University of Münster)
Tura-Ceide, Olga (Institut d'Investigació Biomèdica de Girona)
Guvenc Tuna, B. (Yeditepe University)
Julve i Gil, Josep (Institut de Recerca Sant Pau)
Dogan, S. (Yeditepe University)
Universitat Autònoma de Barcelona

Date:	2025
Abstract:	The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Cardiovascular diseases ; Centenarians ; Health span ; Healthy vascular ageing
Published in:	GeroScience, Vol. 47 Núm. 1 (february 2025) , p. 685-702, ISSN 2509-2723

DOI: 10.1007/s11357-024-01467-8
PMID: 39725804

18 p, 819.2 KB

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