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Documented vaccination as proof of immunity compared to serology in medical students
Godoy, Pere (Institut de Recerca Biomédica (Lleida))
Toledo, Diana (Universitat de Barcelona)
Casas, Irma (Universitat Autònoma de Barcelona)
Colmenares, Karen (Hospital Universitari Vall d'Hebron)
Vilella, Anna (Hospital Clínic i Provincial de Barcelona)
Prat, Andreu (Hospital Clínic i Provincial de Barcelona)
Mormeneo-Bayo, Saray (Hospital Universitari Arnau de Vilanova (Lleida))
Bartolomé Comas, Rosa Maria (Universitat Autònoma de Barcelona)
Ibarz, Mercè (Hospital Universitari Arnau de Vilanova (Lleida))
Domínguez, Ángela (Universitat de Barcelona)

Data: 2025
Resum: We analyzed immunity to vaccine-preventable diseases and the predictive value of documented vaccination versus serological results for medical students in Catalonia (Spain). Epidemiological study of antibody seroprevalence and vaccination in medical students at four teaching units of medicine. Blood samples were drawn from participants who completed an epidemiology questionnaire. For seven diseases, we calculated the positive predictive value (PPV) percentages (and 95% CI) reflecting the protection afforded by self-reported vaccination histories compared to serology results. We enrolled 146 medical students (participation 25. 7%; 146/569), 79. 5% (116/146) women, mean (SD) age 22. 6 (1. 6) years. Most students (84. 2%; 123/146) were fully vaccinated, 18 were unaware of their vaccination status, and 5 students were not vaccinated. Of the six overseas students, only three could document their vaccination status (OR = 6. 0; 95% CI: 1. 1-31. 8). In documented vaccination terms, PPVs for immunological protection were high for varicella (100%), COVID-19 (99. 1%), hepatitis A (98. 9%), and rubella (94. 8%), but was substantially lower for measles (90. 0%), mumps (85. 9%), and hepatitis B (67. 2%). The predictive value of documented vaccination history compared to serology as proof of immunity was above 90% for most vaccines except for measles, mumps, and hepatitis B. OrderedDict([(u'list', OrderedDict([(u'@list-type', u'bullet'), (u'@id', u'list_0001'), (u'list-item', [OrderedDict([(u'p', u'Documented vaccination as immunity evidence was studied for seven vaccine-preventable diseases. ')]), OrderedDict([(u'p', u'Positive predictive values were just 90. 0% for measles, 85. 9% for mumps, and 67. 2% for hepatitis B. ')]), OrderedDict([(u'p', u'To administer booster doses as necessary, documented vaccination for measles, mumps, and hepatitis B should be contrasted with serology results. ')])])]))]).
Ajuts: Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00702
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: Article ; recerca ; Versió publicada
Matèria: Vaccination ; Medical students ; Seroprevalence ; Predictive value
Publicat a: Human vaccines & immunotherapeutics, Vol. 21 (september 2025) , ISSN 2164-554X

DOI: 10.1080/21645515.2025.2556584
PMID: 40963305


10 p, 917.0 KB

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