Synthesis of organic molecules via spray-drying
Pena, Gerard (Universitat Autònoma de Barcelona. Departament de Química)
Albalad Alcala, Jorge (Institut Català de Nanociència i Nanotecnologia)
Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia)
Imaz, Inhar (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2025
Abstract:	Confining chemical reactions within microdroplets has attracted significant attention from chemists due to the accelerated reaction rates resulting from the drastically smaller reaction volumes than in standard solutions. Herein we report that, beyond its widespread use for producing dry-powder formulations for industries (e. g. pharmaceuticals and food) via the atomization of microdroplets followed by drying in a hot gas stream, spray-drying can also be employed in organic synthesis. Specifically, we used spray-drying to run three model reactions: a Schiff-base condensation, a Claisen-Schmidt reaction, and acylation of amines, for synthesizing small organic molecules. Our results showcase that, compared to traditional methods, spray-drying can reduce reaction times without compromising (high) yields, paving the way for its use as a scalable method for industrial-scale organic synthesis.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00458 Agencia Estatal de Investigación CEX2021-001214-S Agencia Estatal de Investigación PID2021-123265NB-I00
Note:	Altres ajuts: CERCA Programme/Generalitat de Catalunya
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Chemical science, Vol. 16, Issue 14 (April 2025) , p. 5770-5775, ISSN 2041-6539

DOI: 10.1039/d5sc00126a
PMID: 40051650

7 p, 741.6 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles