 visitant ::
identificació
|
|||||||||||||||
|
Cerca | Lliura | Ajuda | Servei de Biblioteques | Sobre el DDD | Català English Español | |||||||||
| Pàgina inicial > Articles > Articles publicats > ATG8ylation of vacuolar membrane protects plants against cell wall damage |
(BOKU University) (Vienna BioCenter) (Centre de Recerca en Agrigenòmica) (Max Planck Institute for Plant Breeding Research) (Heidelberg University) (Wageningen University & Research) (Max Planck Institute for Plant Breeding Research) (University of Vienna) (BOKU University) (University of Vienna) (Centre de Recerca en Agrigenòmica) (Swedish University of Agricultural Sciences and Linnean Center for Plant Biology) (Vienna BioCenter)
| Data: | 2025 |
| Resum: | Vacuoles are essential for cellular metabolism and growth and the maintenance of internal turgor pressure. They sequester lytic enzymes, ions and secondary metabolites that, if leaked into the cytosol, could lead to cell death. Despite their pivotal roles, quality control pathways that safeguard vacuolar integrity have remained elusive in plants. Here we describe a conserved vacuolar quality control pathway that is activated upon cell wall damage in a turgor-pressure-dependent manner. Cell wall perturbations induce a distinct modification-ATG8ylation-on the vacuolar membrane (tonoplast) that is regulated by the V-ATPase and ATG8 conjugation machinery. Genetic disruption of tonoplast ATG8ylation impairs vacuolar integrity, leading to cell death. Together, our findings reveal a homeostatic pathway that preserves vacuolar integrity upon cell wall damage. |
| Ajuts: | European Commission 101043370 European Commission 847548 European Commission 101107472 European Commission 101000981 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Plant cell biology ; Stress signalling |
| Publicat a: | Nature plants, Vol. 11 (February 2025) , p. 321-339, ISSN 2055-0278 |
