Male meiosis at the helm : shaping genomes and sex chromosomes in emerging vertebrate models
Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Waters, Paul D (School of Biotechnology and Biomolecular Sciences)
Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)

Date:	2025
Abstract:	The generation of haploid gametes is a hallmark of sexual reproduction achieved through a complex, albeit tightly regulated, reductional cell division known as meiosis. While the molecular underpinnings of meiosis have been extensively characterized in eutherian mammalian models, key aspects-particularly those governing chromosome synapsis and recombination-remain poorly understood in non-eutherian mammals and non-model vertebrates. This knowledge gap is especially relevant for understanding genome evolution, with a focus on sex chromosomes. Comparative studies across diverse vertebrate lineages are therefore essential to uncover conserved and lineage-specific features of meiotic regulation. In this review, we explore the evolutionary dynamics of meiosis in vertebrates, emphasizing how the meiotic program influences genome architecture and the evolution of heteromorphic sex chromosomes, especially the Y chromosome. As research in non-model species gains momentum, dissecting the diversity of meiotic mechanisms across taxa emerges as a key to understanding genome plasticity and evolutionary innovation.
Grants:	Agencia Estatal de Investigación PID2020-112557GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00122 Ministerio de Ciencia, Innovación y Universidades FPU18/03867
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Chromosome inactivation ; Evolution ; Meiosis ; Sex chromosomes ; Vertebrates ; Y chromosome
Published in:	Biology of reproduction, (July 2025) , art. ioaf175, ISSN 1529-7268

DOI: 10.1093/biolre/ioaf175
PMID: 40741968

15 p, 2.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles