A blinded randomised split-body clinical trial evaluating the effect of fluorescent light energy on antimicrobial management of canine interdigital furunculosis
Lange, A. (AniCura Kleintierspezialisten)
Mayer, U. (AniCura Kleintierspezialisten Augsburg GmbH)
Bensignor, E. (Clinique Vétérinaire)
Cornegliani, L. (Clinica Veterinaria S. Siro - Anicura)
Ferreira, D. (Dermatologia Veterinaria)
Matricoti, I. (Servizi Dermatologici Veterinari)
Mosca, M. (Université de Lyon)
Ordeix, Laura (Ordeix i Esteve) (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Pin, D. (Université de Lyon)
Scarampella, F. (Studio Dermatologico Veterinario)
Videmont, E. (Centre Hospitalier Vétérinaire)
Yu, A. (Guelph Veterinary Specialty Hospital)
Fantini, O. (Vetoquinol SA)

Data:	2025
Resum:	Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. This split-body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE) could shorten the time to clinical resolution of CIF and minimise systemic antimicrobial use. Thirty-five client-owned dogs with signs of interdigital furunculosis in at least two paws. This prospective, single-blinded, randomised, split-body multicentre clinical trial treated dogs with systemic antibiotics based on bacterial culture and sensitivity. One paw per dog was randomly selected using a coin-toss method for weekly FLE application, while the other paw served as a control. Dogs were scored every 2 weeks over 56 days on two parameters: a global lesion score (including haemorrhagic vesicles, fistulae with draining tracts, crusts and ulcers) and neutrophils engulfing bacteria score (NES, 0-4). Time to clinical resolution and lesion scores were assessed and compared between groups. At Day (D)28 and D56, the FLE group showed significantly more healed paws (50% and 88%, p = 0. 021) compared to the control (17% and 54%, p = 0. 008). The median time to clinical resolution was shorter for the FLE group (35 days) compared to the control group (56 days, p = 0. 017). No difference in NES score was observed between groups. This blinded, randomised, split-body clinical trial demonstrated that FLE is an effective adjunctive therapy for CIF. It reduces the time to clinical resolution and increases the resolution rate while minimising the need for antibiotics. Background - Canine interdigital furunculosis (CIF) is a complex, relapsing inflammatory condition, typically complicated by deep bacterial infections requiring prolonged systemic antibiotics. Hypothesis/Objectives - This split-body study, where dogs acted as their own control, evaluated whether the adjunctive use of fluorescent light energy (FLE) could shorten the time to clinical resolution of CIF and minimise systemic antibiotic use. Conclusions and Clinical Relevance - This blinded, randomised, split-body clinical trial demonstrated that FLE is an effective adjunctive therapy for CIF. It reduces the time to clinical resolution and increases the resolution rate while minimising the need for antibiotics.
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Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Dog ; Fluorescence photobiomodulation ; Interdigital cysts ; Interdigital furunculosis ; Low-level laser therapy ; Pododermatitis
Publicat a:	Veterinary Dermatology, Vol. 36 (march 2025) , p. 291-301, ISSN 1365-3164

DOI: 10.1111/vde.13340
PMID: 40116237

11 p, 845.8 KB

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